目的:小肠运动障碍是一个广泛的异质性术语,包括由肠运动异常引起的多种胃肠道疾病。慢性假性肠梗阻(CIPO)是一种严重的,罕见,和复杂的小肠运动障碍在这个范围的极端。它的特点是肠道无法推动内容物,尽管没有任何阻塞性病变,但仍会导致肠梗阻的体征和症状。在这篇文章中,我们讨论最新的诊断技术,管理选项,以及CIPO中的组织病理学发现。
结果:我们将强调CIPO患者的最新诊断方法和治疗方案以及肠组织病理学异常。CIPO仍然是一个临床挑战。几种新的药物具有前景,包括胃肠激素激动剂和促动力学。此外,组织病理学检查结果可能有助于指导治疗并提供进一步的预后意义.目前,营养支持,症状管理,避免长期并发症是CIPO治疗的主要手段。
OBJECTIVE: Small bowel dysmotility is a broad heterogeneous term that encompasses a wide range of gastrointestinal disorders resulting from abnormal gut motility. Chronic intestinal pseudo-obstruction (CIPO) is a severe, rare, and complex small bowel motility disorder at the extreme end of this spectrum. It is characterized by failure of the intestinal tract to propel contents, which results in signs and symptoms of bowel obstruction albeit in the absence of any obstructive lesion(s). In this article, we discuss up-to-date diagnostic techniques, management options, and histopathological findings in CIPO.
RESULTS: We will emphasize the latest diagnostic methodologies and therapeutic options as well as enteric histopathologic abnormalities in patients with CIPO. CIPO continues to be a clinical challenge. Several novel pharmacological agents hold promise including gastrointestinal hormone agonists and prokinetics. Furthermore, histopathologic findings may help guide therapy and provide further prognostic significance. At present, nutritional support, symptom management, and avoidance of long-term complications are the mainstay of treatment in CIPO.