■观察性研究表明,肠道菌群与多发性肌炎(PM)和皮肌炎(DM)之间存在关联,但因果关系尚不清楚。我们调查了肠道菌群对PM和DM的因果影响,提供见解,希望为未来的治疗和预防提供见解。
■肠道微生物群的汇总统计来自多种族全基因组关联研究(GWAS)荟萃分析,包括来自18,340个欧洲人的119个分类单元。从GWAS分析中提取PM/DM统计数据。孟德尔随机化(MR)与IVW,MR-Egger,采用加权中位数方法。敏感性分析解决了异质性和多效性。在研究的119个细菌属中,六个显示了因果关系。
■Alloprevotella(OR:3.075,95%CI:1.127-8.386,p=0.028),RuminocycaceaeUCG003(OR:4.219,95%CI:1.227-14.511,p=0.022),Dialister(OR:0.273,95%CI:0.077-0.974,p=0.045)与PM相关。厌氧菌(OR:0.314,95%CI:0.112-0.882,p=0.028),RuminocycaceaeUCG002(OR:2.439,95%CI:1.173-5.071,p=0.017),Sutterella(OR:3.392,95%CI:1.302-8.839,p=0.012)与DM相关。敏感性分析验证了这些关联。
■我们建立了Ruminoccaceae,Sutterilla,AnaerotruncuswithDM,Alloprevotella,RuminocycaceaeUCG003和Dialister与PM。常见的微生物群,像Ruminococaceae,具有重要的临床意义。这些发现为肠道微生物群有助于PM/DM的发展以及未来监测PM/DM患者的肠道微生物群开辟了更大的可能性。
UNASSIGNED: Observational studies suggest associations between gut microbiota and polymyositis (PM) and dermatomyositis (DM), but causal relationships are unclear. We investigate the causal effects of gut microbiota on PM and DM, providing insights hoping to provide insights for future treatment and prevention.
UNASSIGNED: Summary statistics of gut microbiota were obtained from a multi-ethnic Genome Wide Association Studies (GWAS) meta-analysis, including 119 taxa from 18,340 Europeans. PM/DM statistics were extracted from GWAS analyses. Mendelian randomization (MR) with IVW, MR-Egger, and weighted median methods was performed. Sensitivity analyses addressed heterogeneity and pleiotropy. Of the 119 bacterial genera studied, six showed causal links.
UNASSIGNED: Alloprevotella (OR: 3.075, 95% CI: 1.127-8.386, p = 0.028), Ruminococcaceae UCG003 (OR: 4.219, 95% CI: 1.227-14.511, p = 0.022), Dialister (OR: 0.273, 95% CI: 0.077-0.974, p = 0.045) were associated with PM. Anaerotruncus (OR: 0.314, 95% CI: 0.112-0.882, p = 0.028), Ruminococcaceae UCG002 (OR: 2.439, 95% CI: 1.173-5.071, p = 0.017), Sutterella (OR: 3.392, 95% CI: 1.302-8.839, p = 0.012) were related to DM. Sensitivity analyses validated these associations.
UNASSIGNED: We establish causal relationships between Ruminococcaceae, Sutterella, Anaerotruncus with DM, Alloprevotella, Ruminococcaceae UCG003, and Dialister with PM. Common microbiota, like Ruminococcaceae, have significant clinical implications. These findings open up greater possibilities for the gut microbiota to contribute to the development of PM/DM and for future monitoring of the gut microbiota in patients with PM/DM.