这项带有metanalysis的系统综述评估并分析了某些植物性食物单独或与壳聚糖组合食用时对2型糖尿病（T2D）的有益作用。本文的主要目的是研究壳聚糖纳米凝胶与混合食品植物（MFP）控制T2D的关系。数据库包括Medline，Scopus,PubMed,以及Cochrane在1990年1月至2021年1月之间可用。选择研究的资格标准是病例对照研究，包括未成熟的车前草，苦山药,秋葵,和壳聚糖单独使用或与非指定的食用植物（NSFP）组合使用。双重自主评论家检索了所需的信息，并评估了相关研究的偏倚风险。血糖控制的随机效应荟萃分析，被执行了。18项研究的结果包括：7项检查了未成熟的车前草，一个苦山药，两个okras,和八种壳聚糖，关于血糖水平下降的发现。结果的荟萃分析发现，所有研究的I2值占很大比例(98%)，意味着异质性。因此,组合效应大小没有用.相反，使用预测间隔(PI)(平均差4.4mg/dL，95%PI-6.65至15.50，平均差3.4mg/dL，95%PI-23.65至30.50)，而不是其置信区间(CI)的估计值。这些研究的偏倚风险为50％，偏倚风险为50％，并且由于纳入研究方案的信息不足（中度低），因此被认为存在不清楚的偏倚风险。干预持续了3到84天，表明短期和长期干预的效力和有效性。由于研究质量不高，我们谨慎地解释了这些发现.总之,从研究中获得的当前证据确实支持壳聚糖与混合未成熟车前草的关系，苦山药和秋葵用于T2D的管理。需要进一步的高质量病例对照动物研究来证实壳聚糖纳米凝胶是否应该与指定的食品厂（SFP）交联以进行T2D管理。
This systematic
review with metanalysis evaluated and analyzed the beneficial effects of certain plants food in type 2 diabetes (T2D) when consumed alone or in combination with chitosan. The main objective of the paper was to examine the relation of chitosan nanogel and mixed food plant (MFP) to control T2D. The databases included Medline, Scopus, PubMed, as well as Cochrane available between the month of January 1990 to January 2021. The eligibility criteria for selecting studies were case-controlled studies that included unripe plantain, bitter yam, okra, and chitosan either used-alone or in combination with non-specified food plants (NSFP). Two-fold autonomous critics retrieved the information required and evaluated the risk of bias of involved studies. Random-effect meta-analyses on blood glucose controls, were performed. Results of 18 studies included: seven that examined unripe plantains, one bitter yam, two okras, and eight chitosan, found regarding the decrease in blood glucose level. Meta-analysis of the results found a large proportion of I2 values for all studies (98%), meaning heterogeneity. As a consequence, the combined effect sizes were not useful. Instead, prediction interval (PI) was used (mean difference 4.4 mg/dL, 95% PI -6.65 to 15.50 and mean difference 3.4 mg/dL, 95% PI -23.65 to 30.50) rather than the estimate of its confidence interval (CI). These studies were at 50% high risk of bias and 50% low risk of bias and there was judged to be an unclear risk of bias due to the insufficient information from the included study protocol (moderately low). The intervention lasted between three and 84 days, indicating potency and effectiveness of the intervention at both short and long durations. Due to the moderately low quality of the studies, the findings were cautiously interpreted. In conclusion, the current evidence available from the study does support the relation of chitosan with mixed unripe plantain, bitter yam and okra for the management of T2D. Further high-quality case-controlled animal studies are required to substantiate if indeed chitosan nanogel should be cross-linked with the specified food plant (SFP) for the management T2D.
