肥胖是一种以慢性炎症为特征的健康风险,食物的选择与其病因密切相关。我们的目的是调查饮食模式和健康饮食指数(HEI)与超重/肥胖几率和相关炎症指标之间的关系。在一项基于人群的病例对照研究中,我们收集了793名正常体重伊朗人和812名超重/肥胖伊朗人的数据和样本(基于体重指数(BMI)或体表面积(BSA)).饮食摄入量和HEI评分是通过经过验证的124项食物频率问卷获得的。人体测量和社会经济参数,以及血液炎症标志物,被测量。HEI评分较高的参与者血清高密度脂蛋白胆固醇(HDL-C)较高,能量摄入显着降低。超重/肥胖组的水消耗量明显低于对照组。在使用部分相关和控制多个混杂因素的最终模型中,HEI和白细胞介素-4(IL-4,R=-0.063)之间存在显著的负相关,IL-1β(R=-0.054),和高敏C反应蛋白(hs-CRP,R=-0.069)。基于调整了多个混杂因素的多变量逻辑回归模型,HEI作为连续变量(OR=0.993,95%CI:0.988~0.999)和分类变量(OR=0.801,95%CI:0.658~0.977)与BMI组超重/肥胖的几率之间存在显著关联.然而,病例组和对照组的饮食模式相似,我们未能发现HEI与基于BSA的超重/肥胖几率之间存在显著关联。坚持健康饮食建议可能是预防超重/肥胖和保持低炎症指标的谨慎建议。
Obesity is a health risk characterized by chronic inflammation, and food choices are strongly associated with its etiology. Our objective was to investigate the association between dietary patterns and the healthy eating index (HEI) with the odds of overweight/obesity and related inflammatory markers. Within a population-based
case-control study, we collected data and samples from 793 normal-weight and 812 overweight/obese Iranian people (based on either body mass index (BMI) or body surface area (BSA)). Dietary intake and HEI scores were obtained via a validated 124-item food frequency questionnaire. Anthropometric and socioeconomic parameters, as well as blood inflammatory markers, were measured. Participants with higher HEI scores had higher serum high-density lipoprotein-cholesterol (HDL-C) and significantly lower energy intake. Water consumption in the overweight/obese group was significantly lower than in the control group. In the final models using partial correlation and controlling for multiple confounders, there was a significant inverse correlation between HEI and interleukin-4 (IL-4, R = -0.063), IL-1β (R = -0.054), and high-sensitivity C-reactive protein (hs-CRP, R = -0.069). Based on multivariable logistic regression models adjusted for multiple confounders, there was a significant association between HEI as a continuous variable (OR = 0.993, 95% CI: 0.988-0.999) and categorical variable (OR = 0.801, 95% CI: 0.658-0.977) and odds of overweight/obesity across BMI groups. The dietary patterns in the
case and control groups however were similar, and we failed to find a significant association between HEI and odds of overweight/obesity based on BSA. Adherence to healthy eating recommendations may be a prudent recommendation to prevent overweight/obesity and keeping inflammatory indicators low.