■1型糖尿病(T1DM)是一种自身免疫性疾病,其特征是慢性炎症和内皮功能障碍(ED)的原因。心率变异性(HRV)是交感神经和副交感神经自主神经系统功能障碍的标志。我们调查了脂质分布的关联,炎症生物标志物,内皮功能障碍,UAE人群中T1DM青少年的心率变异性。
在这项病例对照研究中,我们从阿布扎比招募了126名青少年(13-22岁),阿联酋(阿拉伯联合酋长国)。人口统计,人体测量学,在禁食过夜后收集血液和尿液样本.根据工作队的建议确定HRV测量值。组间比较采用独立t检验或Mann-WhitneyU检验和Pearson卡方检验。使用调整条件逻辑回归模型来确定与T1DM独立相关的决定因素。
■对照组(n=47)和患者组(n=79)的平均年龄分别为17.5±4.6和18.6±4.8岁,分别。两组之间的糖尿病家族史以及腰围和臀围明显不同(p=0.030和0.010)。T1DM患者的动脉粥样硬化标志物水平明显高于对照组。内皮功能障碍生物标志物,如sICAM-1水平(p<0.001),与T1DM组相比,对照组的脂联素(p<0.001)和25-羟基维生素D(p<0.001)差异有统计学意义。SDNN间隔有显著差异,两组中的NN50、pNN50和SD1/SD2。在调整后的分析中,总胆固醇(调整后的赔率比(aOR):2.78,95%CI:1.37-5.64;p=0.005),LDL(2.66,95CI:1.19-5.92;p=0.017),甘油三酯(5.51,95CI:1.57-19.41;p=0.008)与发展为T1DM显著相关。控制SBP后,HRV指标与T1DM降低几率显著相关,BMI,DM家族史。
■在这项研究中,患有T1DM的青少年显示与血脂谱显著相关,ED,和HRV与对照组比较。因此,需要早期注意糖尿病控制,以降低导致各种心血管疾病的心脏自主神经病变的风险。
UNASSIGNED: Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by the chronic inflammation and cause of endothelial dysfunction (ED). Heart rate variability (HRV) is a marker of sympathetic and parasympathetic autonomic nervous system dysfunction. We investigated the association of lipid profile, inflammatory biomarkers, endothelial dysfunction, and heart rate variability in adolescents with T1DM among UAE population.
UNASSIGNED: In this case-control
study we recruited 126 adolescents (13-22 years) from Abu Dhabi, UAE (United Arab Emirates). Demographic, anthropometric, blood and urine samples were collected after an overnight fasting. HRV measurements were determined per Task Force recommendations. Independent t-test or Mann-Whitney U test and Pearson\'s Chi-squared test were used to compare groups. Adjusted conditional logistic regression model was used to identify the determinants independently associated with T1DM.
UNASSIGNED: The mean ages in control (n = 47) and patient (n = 79) groups were 17.5 ± 4.6 and 18.6 ± 4.8 years, respectively. A family history of diabetes and waist and hip circumferences significantly differed between the groups (p = 0.030 and 0.010). The patients with T1DM exhibited significantly higher levels of atherogenic markers than control. Endothelial dysfunction biomarkers such as levels of sICAM-1 (p < 0.001), adiponectin (p < 0.001) and 25-hydroxyvitamin D (p < 0.001) were significantly different in the control group compared with those in the T1DM group. There was a significant difference in SDNN intervals, NN50, pNN50, and SD1/SD2 among the two groups. In adjusted analysis, total cholesterol (adjusted Odds Ratio (aOR): 2.78, 95 % CI:1.37-5.64; p = 0.005), LDL (2.66, 95%CI:1.19-5.92; p = 0.017), and triglycerides (5.51, 95%CI:1.57-19.41; p = 0.008) were significantly associated with developing T1DM. The HRV indicators were significantly associated with decrease odds of T1DM after controlling for SBP, BMI, and family history of DM.
UNASSIGNED: In this
study, adolescents with T1DM showed a significant association with lipid profile, ED, and HRV compared with controls. Thus, an early attention to diabetes control is required to reduce the risk of cardiac autonomic neuropathy leading to various cardiovascular diseases.