背景:使用计算模型检查组织中癌症进展机制的两个主要问题是缺乏对体内环境中此类事件的有效因素的足够了解,并且在可用的计算模型中缺乏特定参数来模拟此类复杂的反应。
方法:在本研究中,试图通过独立于组织解剖和生理特征的参数来模拟骨组织中癌变的进展,从而降低骨组织的正交各向异性机械性能,一个虚拟的温度是由一个众所周知的框架用于模拟复合材料的损伤。首先,有限元模型的可靠性,以模拟在椎间盘(IVD)的超弹性反应和在骨组件的渐进失败的一些体外试验的模拟进行了验证,在文献中可用。然后,在腰椎多发性骨髓瘤的临床病例中模拟了溶骨损伤的进展。
结果:FE模型可以模拟损伤后椎体的应力屏蔽和扩散,从而导致椎管狭窄。与被检查椎体的前半部和后半部以及后部元素相关的承载份额估计等于41%,47%和12%,分别为完好状态,改为14%,16%和70%,当病变占据椎体的三分之一时。
结论:有限元结果与变形形状的相关性,在临床病例研究的MRI中观察到,表明程序的适当性,提出了用于模拟椎体段的进行性溶骨损伤。未来的研究可能会使用该方法模拟各种转移组织的肿瘤生长,在这里建立。
Two main problems examining the mechanism of cancer progression in the tissues using the computational models are lack of enough knowledge on the effective factors for such events in vivo environments and lack of specific parameters in the available computational models to simulate such complicated reactions.
In this study, it was tried to simulate the progression of cancerous lesions in the bone tissues by an independent parameter from the anatomical and physiological characteristics of the tissues, so to degrade the orthotropic mechanical properties of the bone tissues, a virtual temperature was determined to be used by a well-known framework for simulation of damages in the composite materials. First, the reliability of the FE model to simulate hyperelastic response in the intervertebral discs (IVDs) and progressive failure in the bony components were verified by simulation of some In-Vitro tests, available in the literature. Then, the progression of the osteolytic damage was simulated in a clinical
case with multiple myeloma in the lumbar vertebrae.
The FE model could simulate stress-shielding and diffusion of lesion in the posterior elements of the damaged vertebra which led to spinal stenosis. The load carrying shares associated with the anterior half and the posterior half of the examined vertebral body and the posterior elements were estimated equal to 41 %, 47 % and 12 %, respectively for the intact condition, that changed to 14 %, 16 % and 70 %, when lesion occupied one third of the vertebral body.
Correlation of the FE results with the deformation shapes, observed in the MRIs for the clinical
case study, indicated appropriateness of the procedure, proposed for simulation of the progressive osteolytic damage in the vertebral segments. The future studies may follow simulation of tumor growth for various metastatic tissues using the method, established here.