急诊科的脓毒症管理仍然是日常挑战。幸存的败血症运动(SSC)已经发布了三个小时的捆绑包。这些捆绑在欧洲急诊室的实施情况仍然描述不佳。主要目的是评估对严重脓毒症运动3小时束(血液培养,乳酸用量,第一剂抗生素和30毫升/千克液体挑战)。次要目标是分析严重脓毒症识别和描述人群的延迟。
根据STROBE声明,我们于2015年2月至8月在法国大学医院的两个急诊科进行了一项回顾性研究.使用医院数据库的电子文件对研究期间收治的患者进行筛查。对患者的档案进行审查,并将其纳入研究,如果他们符合严重脓毒症标准。人口统计,合并症,记录治疗。从入院到严重败血症诊断的延迟,计算液体负荷开始和抗生素给药.
纳入130名患者(76名男性,平均年龄71±14岁)。血培养,乳酸用量,在3小时内以%[95%置信区间]100%[96-100%]进行抗生素和30ml/kg液体负荷,62%[54-70%],49%[41-58%]和19%[13-27%],分别。130名患者中有25名(19%[13-27%])符合3小时捆绑的每个标准。平均流体装载体积为18±11ml/kg。出现和严重脓毒症诊断之间的平均延迟为200±263分钟,从诊断到液体挑战和第一次抗生素剂量,10±27分钟和20±55分钟,分别。
必须改善对SSC3-h束的依从性以及入院和败血症识别之间的延迟。如果其他研究证实,可能会部署改进计划。
Sepsis management in the Emergency Department remains a daily challenge. The Surviving Sepsis Campaign (SSC) has released three-hour bundle. The implementation of these
bundles in European Emergency Departments remains poorly described. The main objective was to assess the compliance with the Severe Sepsis Campaign 3-h bundle (blood culture, lactate dosage, first dose of antibiotics and 30 ml/kg fluid challenge). Secondary objectives were the analysis of the delay of severe sepsis recognition and description of the population.
In accordance with STROBE statement, we performed a retrospective
study in two French University Hospital Emergency Departments from February to August 2015. Patients admitted during the
study period were screened using the electronic files of the hospital databases. Patient\'s files were reviewed and included in the
study if they met severe sepsis criteria. Demographics, comorbities, treatments were recorded. Delays from admission to severe sepsis diagnosis, fluid loading onset and antibiotics administration were calculated.
One hundred thirty patients were included (76 men, mean age 71 ± 14 years). Blood culture, lactate dosage, antibiotics and 30 ml/kg fluid loading were performed within 3 hours in % [95% confidence interval] 100% [96-100%], 62% [54-70%], 49% [41-58%] and 19% [13-27%], respectively. 25 patients out of 130 (19% [13-27%]) fulfilled each criteria of the 3-h bundle. The mean fluid loading volume was 18 ± 11 ml/kg. Mean delay between presentation and severe sepsis diagnosis was 200 ± 263 min, from diagnosis to fluid challenge and first antibiotic dose, 10 ± 27 min and 20 ± 55 min, respectively.
Compliance with SSC 3-h bundle and delay between admission and sepsis recognition have to be improved. If confirmed by other studies, an improvement program might be deployed.