博尔纳病病毒1（BoDV-1）可引起以脑膜-骨髓脑炎为特征的严重人类综合征。BoDV-1的实际流行病学仍然存在争议，我们的研究总结了儿童和青少年（<18岁）的患病率数据。通过对三个数据库(PubMed，EMBASE,MedRxiv),所有的研究,包括BoDV-1抗原和特异性抗体的血清阳性率，被找回，并对其结果进行了总结。我们确定了总共六项研究，共2692名年龄小于18岁的受试者（351名受试者针对BoDV-1抗体进行采样，2557名针对抗原进行采样）。最终计算出BoDV-1靶向抗体的合并血清阳性率为6.09％（95％置信区间[95％CI]2.14至16.17），BoDV-1抗原的合并血清阳性率为0.76％（95％CI0.26至2.19）。两种估计都受到实质性异质性的影响。儿童和青少年中BoDV-1的血清阳性率表明病原体确实发生了大量循环，由于婴儿和青少年接触宿主和动物水库的机会相对较少，无法排除未知向量的潜在作用。
Borna disease virus 1 (BoDV-1) can cause a severe human syndrome characterized by meningo-myeloencephalitis. The actual epidemiology of BoDV-1 remains disputed, and our study summarized prevalence data among children and adolescents (<18-year-old). Through systematic research on three databases (PubMed, EMBASE, MedRxiv), all studies, including seroprevalence rates for BoDV-1 antigens and specific antibodies, were retrieved, and their results were summarized. We identified a total of six studies for a total of 2692 subjects aged less than 18 years (351 subjects sampled for BoDV-1 antibodies and 2557 for antigens). A pooled seroprevalence of 6.09% (95% Confidence Interval [95% CI] 2.14 to 16.17) was eventually calculated for BoDV-1 targeting antibodies and 0.76% (95% CI 0.26 to 2.19) for BoDV-1 antigens. Both estimates were affected by substantial heterogeneity. Seroprevalence rates for BoDV-1 in children and adolescents suggested that a substantial circulation of the pathogen does occur, and as infants and adolescents have relatively scarce opportunities for being exposed to hosts and animal reservoirs, the potential role of unknown vectors cannot be ruled out.
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