通过每周一次(每周一次56.5μg)和每周两次特立帕肽(每周两次28.2μg)来更有利地改善皮质骨参数的趋势,显示了每天一次(1/D)特立帕肽(20μg/天,每天一次)的小梁骨参数。
目的:通过基于双能X线吸收法(DXA)的3D建模(3D-SHAPER软件),研究每次给药的特立帕肽(TPTD)量和给药频率的差异对股骨近端骨结构的影响。
方法:这是一项多中心回顾性研究。年龄在50岁或以上的原发性骨质疏松症患者,每周连续接受一次/两次(1·2/W,n=60)或1/DTPTD(n=14)给药至少一年被包括在研究中。测量区域包括股骨颈(FN),转子(TR),股骨干(FS),和全近端髋关节(TH)。同时,测量骨密度(BMD)和骨小梁评分(TBS)。
结果:横截面积,横截面惯性矩,1·2/WTPTD组的FS和截面模量明显改善,与1/DTPTD组相比。然而,在1/DTPTD组中观察到FN的皮质厚度和屈曲比的显着改善,与1・2/WTPTD组相比。在1/DTPTD组中,FS和TH中的小梁BMD值显著增加,与1・2/WTPTD组相比,而TR中的皮质BMD值,FS,在1・2/WTPTD组中,TH显着增加,与1/DTPTD组相比。
结论:观察到1·2/WTPTD对皮质骨和1/DTPTD对小梁骨的改善更有利的趋势。
Trends toward more favorable improvement of the cortical bone parameters by once-weekly (56.5 μg once a week) and twice-weekly teriparatide (28.2 μg twice a week), and that of the trabecular bone parameters by once-daily (1/D) teriparatide (20 μg/day once a day) were shown.
OBJECTIVE: To examine the effects of differences in the amount of teriparatide (TPTD) per administration and its dosing frequency on the bone structure in the proximal femur by dual-energy X-ray absorptiometry (DXA)-based 3D-modeling (3D-SHAPER software).
METHODS: This was a multicenter retrospective
study. Patients aged 50 years or older with primary osteoporosis who continuously received once-/twice-weekly (1・2/W, n = 60) or 1/D TPTD (n = 14) administration for at least one year were included in the
study. Measurement regions included the femoral neck (FN), trochanter (TR), femoral shaft (FS), and total proximal hip (TH). Concurrently, the bone mineral density (BMD) and Trabecular Bone Score (TBS) were measured.
RESULTS: The cross-sectional area, cross-sectional moment of inertia, and section modulus in the FS were significantly improved in the 1・2/W TPTD group, as compared to the 1/D TPTD group. However, significant improvement of the cortical thickness and buckling ratio in the FN was observed in the 1/D TPTD group, as compared to the 1・2/W TPTD group. Trabecular BMD values in the FS and TH were significantly increased in the 1/D TPTD group, as compared to the 1・2/W TPTD group, while the cortical BMD values in the TR, FS, and TH were significantly increased in the 1・2/W TPTD group, as compared to the 1/D TPTD group.
CONCLUSIONS: Trends toward more favorable improvement of the cortical bone by 1・2/W TPTD and that of the trabecular bones by 1/D TPTD were observed.