此案例研究描述了在德国南部的AI中心，公猪床上用品被有毒化合物污染的影响。调查的起源是公猪的产量急剧下降。2021年7月，超过54％的公猪没有生产，超过45％的射精精子质量和数量不足，与其他月份相比，这是一个显著的下降。这种下降伴随着少精子症（无精子症），弱精子症和畸形精子症。通过密集的故障排除，这些变化可以归因于fenpropropimoph，一种具有潜在毒性的抑制麦角甾醇生物合成的杀菌剂，在用作床上用品的锯末以及受影响动物的肝脏样本中发现，分别达到0.20±0.36mg/kg和0.019±0.001mg/kg之间的浓度（平均值±SD）。此外，尸检结果显示睾丸充血,生发上皮的组织学局灶性变性和精子发生和精子发生减少的迹象。
This
case study describes the effects of a contamination of boar bedding material with reprotoxic compounds in an AI centre in southern Germany. The origin of the investigations was an extreme decline in the production output of the boars. In July 2021, more than 54% of boars were not in production and over 45% of ejaculates had insufficient sperm quality and quantity, which is a significant drop in comparison with the other months. This drop was accompanied by oligozoospermia (azoospermia), asthenozoospermia and teratozoospermia. Through intensive troubleshooting, the changes could be attributed to fenpropimorph, an ergosterol biosynthesis-inhibiting fungicide with reprotoxic potential, which was found in the sawdust used as bedding as well as in liver samples of affected animals, reaching a concentration (mean ± SD) between 0.20 ± 0.36 mg/kg and 0.019 ± 0.001 mg/kg respectively. Furthermore, autopsy findings revealed hyperaemia of the testis, histologically focal degeneration of the germinal epithelium and signs of reduced spermatogenesis and spermiogenesis.
