脂质体是公认的和必需的纳米大小的药物递送系统。脂质体是由细胞膜组分组成的磷脂囊泡,并且已经被用作模拟细胞的结构和功能的人工细胞模型,并且在各种生物学分析中具有巨大的用途。脂质体在临床前和临床试验中作为有用的药物载体获得了巨大的优势并提供了广泛的应用。这篇综述专门总结了脂质体制备的可扩展技术,并着重于工业适用性的优势和局限性。此外,这篇综述讨论了生物医学应用的最新进展,并提到了市售制剂的主要亮点,最近的临床试验和专利。此外,这篇综述还提供了分类的简要信息,脂质体的组成和表征。
Liposomes are well-recognized and essential nano-sized drug delivery systems. Liposomes are phospholipid vesicles comprised of cell membrane components and have been employed as artificial cell models to mimic structure and functions of cells and are of immense use in various biological analyses. Liposomes acquire great advantages and provide wide range of applications as useful drug carriers in pre-clinical and clinical trials. This
review summarizes exclusively on scalable techniques for liposome preparation and focuses on the strengths and limitations with respect to industrial applicability. Also, this
review discusses the updated recent advancements in biomedical applications with a mention of key highlights of commercially available formulations, clinical trials and patents in recent past. Furthermore, this
review also provides brief information of the classification, composition and characterization of liposomes.