过敏性鼻炎继续在成人和儿科人群中构成全球负担,需要适当的药物治疗以避免长期并发症,这使其成为一个具有挑战性的问题。这提示需要找到针对这种情况的合适和适当的治疗方案。
■研究口服比拉斯汀和益生菌对过敏性鼻炎患者的临床疗效。比较比拉斯汀单药与口服比拉斯汀联合益生菌治疗变应性鼻炎的疗效。
■总共选择了100名患者,并随机分为两组-第1组和第2组,分别口服Bilastine20mgOD和口服Bilastine20mg口服益生菌OD(发酵乳杆菌和副干酪乳杆菌-40亿个细胞)以维持均匀性。基线评分和6周后的随访评分采用总症状评分,绝对嗜酸性粒细胞计数和鼻腔涂片嗜酸性粒细胞计数,并根据其对治疗的反应进行评估和记录。
■观察到症状尤其是鼻塞的严重程度显着降低,两组患者的喷嚏以及额外的鼻部症状,治疗前第1组的平均得分为7.72,降至3.66,第2组的平均得分为9.32至5.02。第2组的平均评分在治疗前和治疗后都更高,这是非常显著的。(p<0.001)。
■口服比拉斯汀的单一疗法已被证明可以缓解过敏症状。口服益生菌与Bilastine一起添加已显示在进一步改善过敏性鼻炎的整体症状方面具有协同作用。
UNASSIGNED: Allergic rhinitis continues to pose a global burden in both adult and paediatric population and requires adequate medical therapy to avoid long term complications making it a challenging concern. This prompts the need to find a suitable and appropriate treatment regimen for this condition.
UNASSIGNED: To study the clinical efficacy of Oral
Bilastine and Probiotics in patients with allergic rhinitis. To compare the effectiveness of
Bilastine monotherapy to Oral
Bilastine combined with Probiotics in patients with allergic rhinitis.
UNASSIGNED: Total of 100 patients were selected and randomized into two groups- Group 1 and Group 2 and were treated with Oral Bilastine 20 mg OD and Oral
Bilastine 20 mg with Oral Probiotics OD (Lactobacillus fermentum & L. paracasei - 4 billion cells) respectively to maintain uniformity. Baseline scoring and follow up scoring after 6 weeks was done using the Total symptom score, Absolute eosinophil count and Nasal smear eosinophil count and were evaluated and documented as per their response to treatment.
UNASSIGNED: A significant reduction was observed in the severity of symptoms especially nasal obstruction, sneezing in patients of both groups along with extra nasal symptoms, with average mean score in Group 1 being 7.72 before treatment that reduced to 3.66 and that of Group 2 from 9.32 to 5.02. The mean score of Group 2 was greater in both before and after treatment which is highly significant. (p < 0.001).
UNASSIGNED: Monotherapy with Oral
Bilastine has proven in relieving allergic symptoms. Addition of Oral Probiotics along with
Bilastine has shown to have synergistic effect in further improving overall symptoms in allergic rhinitis.