目的:放疗指南的依从性对于维持治疗质量和一致性至关重要,特别是在大多数治疗发生的非试验患者环境中。该研究旨在评估指南更改对治疗计划实践的影响,并将手动注册数据的准确性与治疗计划数据进行比较。
方法:这项研究利用了DBCGRTNation队列,丹麦的乳腺癌放射治疗数据集,评估2008年至2016年对指南的遵守情况。该队列包括7448例高危乳腺癌患者。国家准则的变化包括,分馏,引入呼吸门控,乳腺内淋巴结的照射,在描绘实践中使用同时集成的增强技术和左前下降冠状动脉的纳入。结构名称映射的方法,侧向性检测,检测人群平均肺容积的时间变化,和剂量评估进行了介绍和应用。从丹麦乳腺癌数据库获得手动登记的治疗特征数据用于比较。
结果:研究发现,丹麦放疗中心立即且一致地遵守指南变更。指南实施之前的治疗实践已记录在案,并显示各中心之间存在差异。对于某些措施,手动注册数据与实际治疗计划数据之间的差异高达10%。
结论:可以在常规治疗数据中检测到国家指南的变化,具有高度的合规性和较短的实施时间。与医疗登记数据相比,从治疗计划数据文件提取的数据提供了更准确和详细的治疗和指南依从性表征。
OBJECTIVE: Guideline adherence in radiotherapy is crucial for maintaining treatment quality and consistency, particularly in non-trial patient settings where most treatments occur. The study aimed to assess the impact of
guideline changes on treatment planning practices and compare manual registry data accuracy with treatment planning data.
METHODS: This study utilised the DBCG RT Nation cohort, a collection of breast cancer radiotherapy data in Denmark, to evaluate adherence to
guidelines from 2008 to 2016. The cohort included 7448 high-risk breast cancer patients. National
guideline changes included, fractionation, introduction of respiratory gating, irradiation of the internal mammary lymph nodes, use of the simultaneous integrated boost technique and inclusion of the Left Anterior Descending coronary artery in delineation practice. Methods for structure name mapping, laterality detection, detection of temporal changes in population mean lung volume, and dose evaluation were presented and applied. Manually registered treatment characteristic data was obtained from the Danish Breast Cancer Database for comparison.
RESULTS: The study found immediate and consistent adherence to guideline changes across Danish radiotherapy centres. Treatment practices before
guideline implementation were documented and showed a variation among centres. Discrepancies between manual registry data and actual treatment planning data were as high as 10% for some measures.
CONCLUSIONS: National guideline changes could be detected in the routine treatment data, with a high degree of compliance and short implementation time. Data extracted from treatment planning data files provides a more accurate and detailed characterisation of treatments and guideline adherence than medical register data.