■神经c细胞(NCC)是多能的,并且归因于复杂的多峰基因调控机制的组合。心脏神经c(CNC)细胞,起源于背侧神经管,是心血管神经血管领域的关键建筑师,协调关键心脏和血管结构的胚胎发生。值得注意的是,虽然科学界在20世纪80年代初编制了一份神经脊衍生物的综合清单,我们对CNC在各种心血管疾病过程中的作用的理解仍然需要探索。这篇综述深入探讨了NCC的差异化,特别是CNC单元,并探讨了非综合征性心血管神经病理学的不同方面。
■根据PRISMA声明进行了系统审查。三个著名的数据库,PubMed,Scopus,和Embase,被搜查,产生了1840项研究。我们排除了1,796项研究,最终选择的44项研究构成了这次全面审查的基础。
■神经病理学是一组影响NC细胞发育的遗传性疾病。心血管神经病变,即,心脏病和血管病变,与NCC相关的可能以(1)心脏间隔疾病的形式发生,主要是主动脉-肺动脉间隔;(2)大血管和血管疾病;(3)心肌功能障碍;(4)所有三种表型的组合。这可能是由于NCC迁移异常导致的,分化,或导致结构异常的增殖,归因于遗传,家族性,零星的或后天的原因。
■心血管神经病变的表型特征,如二叶主动脉瓣和胸主动脉瘤,有一个共同的胚胎起源,在普通人群中非常普遍,需要进一步研究以确定导致这些心脏异常的潜在致病和遗传因素。这些发现对于加强诊断筛查和完善治疗干预措施至关重要。最终改善受这些条件影响的个人的生活。
UNASSIGNED: Neural crest cells (NCCs) are multipotent and are attributed to the combination of complex multimodal gene regulatory mechanisms. Cardiac neural crest (CNC) cells, originating from the dorsal neural tube, are pivotal architects of the cardio-neuro-vascular domain, which orchestrates the embryogenesis of critical cardiac and vascular structures. Remarkably, while the scientific community compiled a comprehensive inventory of neural crest derivatives by the early 1980s, our understanding of the CNC\'s role in various cardiovascular disease processes still needs to be explored. This
review delves into the differentiation of NCC, specifically the CNC cells, and explores the diverse facets of non-syndromic cardiovascular neurocristopathies.
UNASSIGNED: A systematic
review was conducted as per the PRISMA Statement. Three prominent databases, PubMed, Scopus, and Embase, were searched, which yielded 1,840 studies. We excluded 1,796 studies, and the final selection of 44 studies formed the basis of this comprehensive
review.
UNASSIGNED: Neurocristopathies are a group of genetic disorders that affect the development of cells derived from the NC. Cardiovascular neurocristopathy, i.e., cardiopathy and vasculopathy, associated with the NCC could occur in the form of (1) cardiac septation disorders, mainly the aortico-pulmonary septum; (2) great vessels and vascular disorders; (3) myocardial dysfunction; and (4) a combination of all three phenotypes. This could result from abnormalities in NCC migration, differentiation, or proliferation leading to structural abnormalities and are attributed to genetic, familial, sporadic or acquired causes.
UNASSIGNED: Phenotypic characteristics of cardiovascular neurocristopathies, such as bicuspid aortic valve and thoracic aortic aneurysm, share a common embryonic origin and are surprisingly prevalent in the general population, necessitating further research to identify the underlying pathogenic and genetic factors responsible for these cardiac anomalies. Such discoveries are essential for enhancing diagnostic screening and refining therapeutic interventions, ultimately improving the lives of individuals affected by these conditions.