空气污染每年造成近500万人死亡,伤害数十亿人。在世界许多地方,空气污染水平仍然非常高,据报道,城市化地区与空气污染相关的过早死亡,特别是与空气中纳米和超细颗粒的存在有关。
到目前为止,大多数研究都集中在空气污染对人体心血管和呼吸系统的不利影响上。虽然皮肤与空气污染物直接接触,它们对皮肤的损害作用仍在调查中。流行病学数据表明,暴露于空气污染物与慢性免疫性皮肤病症状加重之间存在相关性。在这项研究中,进行了系统的文献综述,以了解有关空气中颗粒物对人体皮肤影响的最新知识。它旨在更深入地了解空气污染物与皮肤之间的相互作用,以进一步评估其对人类健康的潜在风险。
颗粒物质被证明会诱导皮肤屏障功能障碍,并通过直接和间接机制引起活性氧的形成,导致氧化应激并诱导人皮肤炎症级联反应的激活。此外,据报道,随着颗粒物暴露量的增加,外在衰老和特应性湿疹的相对风险呈正相关.
Air pollution is killing close to 5 million people a year, and harming billions more. Air pollution levels remain extremely high in many parts of the world, and air pollution-associated premature deaths have been reported for urbanized areas, particularly linked to the presence of airborne nano-sized and ultrafine particles.
To date, most of the research studies did focus on the adverse effects of air pollution on the human cardiovascular and respiratory systems. Although the skin is in direct contact with air pollutants, their damaging effects on the skin are still under investigation. Epidemiological data suggested a correlation between exposure to air pollutants and aggravation of symptoms of chronic immunological skin diseases. In this study, a systematic literature
review was conducted to understand the current knowledge on the effects of airborne particulate matter on human skin. It aims at providing a deeper understanding of the interactions between air pollutants and skin to further assess their potential risks for human health.
Particulate matter was shown to induce a skin barrier dysfunction and provoke the formation of reactive oxygen species through direct and indirect mechanisms, leading to oxidative stress and induced activation of the inflammatory cascade in human skin. Moreover, a positive correlation was reported between extrinsic aging and atopic eczema relative risk with increasing particulate matter exposure.