UNASSIGNED:这项研究包括使用两阶段程序进行全层皮肤重建的患者,包括碱性成纤维细胞生长因子浸渍的胶原明胶海绵(bFGF-CGS)植入和自体皮肤移植,在等待<2周或≥2周后接受自体皮肤移植的患者组之间比较皮肤移植率。
未经批准:急性,全层皮肤缺损采用污染/坏死组织彻底清创术治疗,然后用生理盐水冲洗和电灼止血。然后,使用不可吸收缝线将FGF-CGS固定在皮肤缺损伤口上,在确认有足够的真皮样组织再生后,进行第二阶段自体皮肤移植术以闭合伤口.根据第二次手术前的等待时间将患者分为两组,即,<2周(早期组)和≥2周(晚期组),比较了植皮率。
未经评估:我们登记并治疗了25例(18名男性,7名妇女;平均年龄:49[范围2-86]岁)。早期组的平均植皮率为93%(范围80%-100%),晚期组的平均植皮率为92%(范围65%-100%)。两组间无显著性差异。两组之间的平均完全愈合时间有显着差异:早期组25.2±9.7天,晚期组44.7±27天(p<0.05)。
UNASSIGNED:我们的数据表明,bFGF-CGF可以在2周内形成具有足够质量的真皮样肉芽组织,作为皮肤移植的移植床。
UNASSIGNED: This
study included patients who underwent full-thickness skin reconstruction using a two-stage procedure comprising basic fibroblast growth factor-impregnated collagen gelatin sponge (bFGF-CGS) implantation and autologous skin grafting, and the take rate of skin grafts was compared between groups of patients who underwent autologous skin grafting after a waiting period of <2 weeks or ≥2 weeks.
UNASSIGNED: An acute, full-thickness skin defect was treated with thorough debridement of contaminated/necrotic tissue, followed by washing with saline and hemostasis with electrocautery. Then, an FGF-CGS was fixed to the skin defect wound using non-absorbable sutures, and after confirming regeneration of sufficient dermis-like tissue, the second-stage autologous skin grafting was performed for wound closure. Patients were divided into two groups according to the waiting period before the second operation, namely, <2 weeks (early group) and ≥2 weeks (late group), and the take rate of skin grafts was compared.
UNASSIGNED: We enrolled and treated 25 cases (18 men, 7 women; mean age: 49 [range 2-86] years). The mean take rate of skin grafts was 93% (range 80%-100%) in the early group and 92% (range 65%-100%) in the late group, with no significant difference between the two groups. There was a significant difference between the groups in mean time to complete healing: 25.2 ± 9.7 days in the early group vs 44.7 ± 27 days in the late group (p < 0.05).
UNASSIGNED: Our data suggest that bFGF-CGF can form dermis-like granulation tissue with sufficient quality as a graft bed for skin transplantation within 2 weeks.