■我们旨在研究肾脏清除率增加(ARC)的患病率,并验证ARC和ARCTIC评分的实用性。我们还旨在评估估计的GFR(eGFR-EPI)和8小时测量的肌酐清除率(8hr-mCLcr)之间的相关性和一致性。
■这是一个前景,我们在内科-外科混合重症监护病房(ICU)进行了观察性研究,纳入了90例患者.8小时-mCLcr,ARC,计算所有患者的ARCTIC评分和eGFR-EPI。如果8hr-mCLcr≥130mL/min,则认为存在ARC。
■4名患者被排除在分析之外。ARC的患病率为31.4%。敏感性,特异性,ARC和ARCTIC评分的阳性和阴性预测值分别为55.6,84.7,62.5,80.6和85.2,67.8,54.8和90.9.ARC和ARCTIC评分的AUROC分别为0.802和0.765。在eGFR-EPI和8小时-mCLcr之间观察到强的正相关和差的一致性。
■ARC的患病率显着,ARCTIC评分显示出作为预测ARC的筛查工具的良好潜力。将ARC评分的截止值降低到≥5可以提高其预测ARC的实用性。尽管与8hr-mCLcr的协议不佳,截止值≥114mL/min的eGFR-EPI在预测ARC方面显示出实用性。
■KannaG,PatodiaS,AnnigeriRA,RamakrishnanN,VenkataramanR.增加肾脏清除率(ARC)的患病率,增强肾脏清除率评分系统(ARC评分)和增强肾脏清除率在创伤重症监护评分系统(ARCTIC评分)中预测重症监护病房ARC的实用性:前瞻性研究。印度J暴击护理中心2023;27(6):433-443。
UNASSIGNED: We aimed to
study the prevalence of augmented renal clearance (ARC) and validate the utility of ARC and ARCTIC scores. We also aimed to assess the correlation and agreement between estimated GFR (eGFR-EPI) and 8-hour measured creatinine clearance (8 hr-mCLcr).
UNASSIGNED: This was a prospective, observational
study done in the mixed medical-surgical intensive care unit (ICU) and 90 patients were recruited. 8 hr-mCLcr, ARC, and ARCTIC scores and eGFR-EPI were calculated for all patients. ARC was said to be present if 8 hr-mCLcr was ≥ 130 mL/min.
UNASSIGNED: Four patients were excluded from the analysis. The prevalence of ARC was 31.4%. The sensitivity, specificity, and positive and negative predictive values of ARC and ARCTIC scores were found to be 55.6, 84.7, 62.5, 80.6, and 85.2, 67.8, 54.8, and 90.9 respectively. AUROC for ARC and ARCTIC scores were 0.802 and 0.765 respectively. A strong positive correlation and poor agreement were observed between eGFR-EPI and 8 hr-mCLcr.
UNASSIGNED: The prevalence of ARC was significant and the ARCTIC score showed good potential as a screening tool to predict ARC. Lowering the cut-off of ARC score to ≥5 improved its utility in predicting ARC. Despite its poor agreement with 8 hr-mCLcr, eGFR-EPI with a cut-off ≥114 mL/min showed utility in predicting ARC.
UNASSIGNED: Kanna G, Patodia S, Annigeri RA, Ramakrishnan N, Venkataraman R. Prevalence of Augmented Renal Clearance (ARC), Utility of Augmented Renal Clearance Scoring System (ARC score) and Augmented Renal Clearance in Trauma Intensive Care Scoring System (ARCTIC score) in Predicting ARC in the Intensive Care Unit: Proactive
Study. Indian J Crit Care Med 2023;27(6):433-443.