■神经肌肉阻滞的开始时间是与缺氧和肺吸入风险相关的关键时间。已经采取了各种策略来缩短这种开始时间。因此,我们调查了20ml盐水推注后肢体抬高的影响,以0.6mg/kg的剂量给予罗库溴铵,以研究起效时间。
■30名患者被随机分配到推注盐水组和对照组。用芬太尼和丙泊酚诱导并维持全身麻醉。在研究组中,静脉内(IV)施用罗库溴铵0.6mg/kg,然后进行20ml盐水推注和肢体抬高,而对照组仅在连续滴注中施用0.6mg/kg。神经肌肉阻滞的发作是通过四组刺激的内收肌加速肌造影评估的。
■推注组(中位数34s)的滞后时间比对照组(中位数45s)短,P<0.017。推注组的起效时间(中位数55s)短于对照组(中位数110s),P<0.001。推注组(中位数42分钟)的T1恢复到25%比对照组(中位数39分钟)更长,这在统计学上没有显着意义。
■罗库溴铵0.6mg/kg静脉注射,然后推注20ml盐水和伴随的肢体抬高导致更短的滞后时间,神经肌肉阻滞的更快发作,与对照组相比,良好的插管条件没有延长临床作用持续时间。
UNASSIGNED: The onset time of neuromuscular blockade is a crucial time associated with the risk of hypoxia and pulmonary aspiration. Various strategies have been undertaken to shorten this onset time. Therefore, we investigated the effects of bolus of 20 ml saline followed by limb elevation after administration of rocuronium in a dose of 0.6 mg/kg to
study the onset time.
UNASSIGNED: Thirty patients were randomly allocated to the bolus saline group or control group. General anesthesia was induced and maintained with fentanyl and propofol. Rocuronium 0.6 mg/kg intravenous (IV) was administered followed by 20 ml saline bolus and limb elevation in the
study group compared to administration of 0.6 mg/kg in a running drip only in the control. Onset of neuromuscular block was assessed by acceleromyography at the adductor pollicis muscle with train-of-four stimulation.
UNASSIGNED: The lag time was shorter in bolus group (34 s median) than in control group (45 s median), P < 0.017. The onset time was shorter in bolus group (55 s median) than in control group (110 s median), P < 0.001. The T1 recovery to 25% was longer in bolus group (42 min median) than in control group (39 min median) which was statistically not significant.
UNASSIGNED: Rocuronium 0.6 mg/kg IV followed by bolus 20 ml saline and concomitant limb elevation resulted in shorter lag time, faster onset of neuromuscular blockade, good intubating conditions without prolonging clinical duration of action when compared to the control.