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  • 文章类型: Journal Article
    从古病理学到法医分类学,人类木乃伊尸体构成了至关重要的生物档案。内生物和异源生物的毒理学分析已经显示出对考古木乃伊研究和重金属检测的价值,镇静催眠药物,和兴奋剂。由于在头发和指甲中检测药物的大窗口,从这些研究中获得的信息增加了科学界对过去人群生活方式的了解。尽管如此,关于法医环境中木乃伊尸体的毒理学报告,几乎没有书目参考。这里,作者旨在提请注意毒理学分析的宝贵贡献,同时考虑到以前进行的研究及其发现。鉴于从法医场景中收集木乃伊尸体的样本可能并不总是在实验室或尸检室进行,作者还提出了一套法医木乃伊原位取样指南。预计本技术说明将鼓励专家对木乃伊尸体进行毒理学分析,并更频繁地发布病例报告。
    From palaeopathology to forensic taphonomy, mummified human bodies constitute biological archives of paramount importance. Toxicology analysis of endobiotics and xenobiotics has already shown value to archaeological mummies research with detecting heavy metals, sedative-hypnotic drugs, and stimulants. Thanks to the large window of drug detection in hair and nails, the information from such studies has increased the scientific community\'s knowledge regarding past populations\' lifestyles. Still, few bibliographic references exist regarding toxicology reports in mummified bodies from forensic settings. Here, the authors aim to draw attention to the valuable contribution of toxicology analysis, taking into account previously conducted studies and their findings. Given that sample collection on mummified bodies from forensic scenarios may not always happen in laboratories or autopsy rooms, the authors also suggest guidelines for in situ sampling of forensic mummies. It is expected that the present technical note will encourage experts to perform toxicology analysis in mummified bodies and publish their case reports more often.
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  • 文章类型: Journal Article
    OBJECTIVE: Formalin-fixed, paraffin-embedded unstained archived diagnostic tissue sections are frequently exchanged between clinical laboratories for immunohistochemical staining. The manner in which such sections are prepared represents a type of preanalytical variable that must be taken into account given the growing importance of immunohistochemical assays, especially predictive and prognostic tests, in personalized medicine.
    METHODS: Recommendations were derived from review of the literature and expert consensus of the Canadian Association of Pathologists-Association canadienne des pathologists National Standards Committee for High Complexity Testing/Immunohistochemistry.
    RESULTS: Relevant considerations include the type of glass slide on which to mount the unstained sections; the thickness of the tissue sections; the time from slide preparation to testing; the environment, particularly the temperature at which the unstained sections will be maintained prior to testing; the inclusion of on-slide positive control tissue where possible; and whether patient identifier(s) should be included on slide labels.
    CONCLUSIONS: Clear communication between requesting and releasing laboratories will facilitate the proper preparation of unstained sections and also ensure that applicable privacy considerations are addressed.
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    文章类型: English Abstract
    为了充分履行其许多不同的任务作为一个学者\'社会和作为德国国家科学院,德意志银行需要在历史背景下看待自己。这只能作为纪念文化的一部分发生,这种文化促进了对利奥波迪纳过去的记忆,并在科学和学术历史的背景下对其进行了批判性分析。新成立的Leopoldina科学史研究中心和科学院将成为一个论坛,在Leopoldina追求既定的历史研究形式,组织新的科学项目,并向公众展示其发现。目的是让尽可能多的Leopoldina成员参与其所有学科,以及与国家和国际合作伙伴合作。
    In order to adequately perform its many diverse tasks as a scholars\' society and as the German National Academy of Sciences, the Deutsche Akademie der Naturforscher Leopoldina needs to view itself in a historical context. This can only happen as part of a culture of remembrance which fosters the memory of the Leopoldina\'s past and subjects this to a critical analysis in the context of the history of science and academies. The newly founded Leopoldina Study Center for the History of Science and Science Academies is to be a forum that pursues established forms of historical research at the Leopoldina, organizes new scientific projects, and presents its findings to the public. The aim is to involve as many Leopoldina members as possible from all of its disciplines, as well as to collaborate with national and international partners.
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  • 文章类型: Evaluation Study
    The CMA Infobase is a free Web-based resource that contains evidence-based clinical practice guidelines. The database is maintained by the Canadian Medical Association (CMA) and is available on its Web site. The CMA Infobase currently contains 1,200-plus clinical practice guidelines either developed or endorsed by an authoritative health care organization located in Canada. It is an alternative source of free clinical practice guidelines to the National Guideline Clearinghouse. This column will cover the basics of CMA Infobase, including searching, special features, and available resources which complement the database.
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  • 文章类型: Guideline
    暂无摘要。
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    文章类型: Journal Article
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