沸石和沸石咪唑酯骨架(ZIFs)作为携带药物的纳米平台被广泛研究,以增强传统抗癌药物的特异性和功效。目前,没有其他系统评价评估沸石/ZIFs作为抗癌药物载体的效力。由于沸石/ZIF的多孔性质和固有的pH敏感特性,该化合物可将抗癌药物截留并选择性释放到酸性肿瘤微环境中。因此,提供有关该主题的现有证据的全面概述,以确定该化合物的益处以及潜在的知识空白是很有价值的。这项研究的目的是评估沸石/ZIF作为递送阿霉素(DOX)的药物递送系统的潜在治疗应用,5-氟尿嘧啶(5-FU),姜黄素,顺铂,还有miR-34a.按照PRISMA准则,对PubMed的详尽搜索,Scopus,Embase,进行了WebofScience。截至2021年8月25日,没有使用语言或时间限制。仅选择与沸石/ZIF在递送抗癌药物中的用途有关的全文文章。最初,1279项研究被确定,其中572条重复记录被排除在外。筛选标题后,abstract,和全文,保留了53篇文章,并包括在定性综合中。评估者间可靠性(IRR)测试,其中包括用户协议百分比和可靠性百分比,是为53篇文章进行的。所包括的研究表明,掺入抗癌药物的沸石/ZIF可用作替代治疗选择,以通过减轻常规治疗下药物的缺点来增强癌症治疗的功效。
Zeolites and zeolitic imidazolate frameworks (ZIFs) are widely studied as drug carrying nanoplatforms to enhance the specificity and efficacy of traditional anticancer drugs. At present, there is no other systematic
review that assesses the potency of zeolites/ZIFs as anticancer drug carriers. Due to the porous nature and inherent pH-sensitive properties of zeolites/ZIFs, the compounds can entrap and selectively release anticancer drugs into the acidic tumor microenvironment. Therefore, it is valuable to provide a comprehensive overview of available evidence on the topic to identify the benefits of the compound as well as potential gaps in knowledge. The purpose of this study was to evaluate the potential therapeutic applications of zeolites/ZIFs as drug delivery systems delivering doxorubicin (DOX), 5-fluorouracil (5-FU), curcumin, cisplatin, and miR-34a. Following PRISMA guidelines, an exhaustive search of PubMed, Scopus, Embase, and Web of Science was conducted. No language or time limitations were used up to 25th August 2021. Only full text articles were selected that pertained to the usage of zeolites/ZIFs in delivering anticancer drugs. Initially, 1279 studies were identified, of which 572 duplicate records were excluded. After screening for the title, abstract, and full texts, 53 articles remained and were included in the qualitative synthesis. An Inter-Rater Reliability (IRR) test, which included a percent user agreement and reliability percent, was conducted for the 53 articles. The included studies suggest that anticancer drug-incorporated zeolites/ZIFs can be used as alternative treatment options to enhance the efficacy of cancer treatment by mitigating the drawbacks of drugs under conventional treatment.