背景:只有一小部分精神分裂症患者出现紧张性症状。影像学研究表明,大脑运动回路与紧张症的潜在病理有关。然而,有关紧张型精神分裂症中这些回路的扩散性失调的数据很少。
目的:评估精神分裂症伴紧张症患者的脑运动回路受累情况。
方法:使用扩散张量成像(DTI)测量与运动电路链接的选定大脑区域中的白质信号。将7例紧张型精神分裂症患者的相关DTI数据与7例非紧张型精神分裂症患者的DTI数据进行了比较,匹配性别,年龄,和教育水平。
结果:在call体的脾中发现了显着升高的分数各向异性值,小脑的右花梗,与没有卡通症的精神分裂症患者相比,右内囊。这一发现表明,在选定的运动相关的大脑区域中,扩散率发生了改变。
结论:紧张型精神分裂症与特定运动脑区和相应回路的连接失调有关。需要进行未来的DTI研究,以解决精神分裂症相关紧张症在急性和缓解状态下的运动异常的神经相关性,以确定该疾病的特定病理生理学。
BACKGROUND: Only a small proportion of schizophrenia patients present with catatonic symptoms. Imaging studies suggest that brain motor circuits are involved in the underlying pathology of catatonia. However, data about diffusivity dysregulation of these circuits in catatonic schizophrenia are scarce.
OBJECTIVE: To assess the involvement of brain motor circuits in schizophrenia patients with catatonia.
METHODS: Diffusion tensor imaging (DTI) was used to measure white matter signals in selected brain regions linked to motor circuits. Relevant DTI data of seven catatonic schizophrenia patients were compared to those of seven non-catatonic schizophrenia patients, matched for sex, age, and education level.
RESULTS: Significantly elevated fractional
anisotropy values were found in the splenium of the corpus callosum, the right peduncle of the cerebellum, and the right internal capsule of the schizophrenia patients with catatonia compared to those without catatonia. This finding showed altered diffusivity in selected motor-related brain areas.
CONCLUSIONS: Catatonic schizophrenia is associated with dysregulation of the connectivity in specific motoric brain regions and corresponding circuits. Future DTI studies are needed to address the neural correlates of motor abnormalities in schizophrenia-related catatonia during the acute and remitted state of the illness to identify the specific pathophysiology of this disorder.