背景:鉴于当前报道的动物实验的不足和不完整以及它们的总体质量差,我们根据《动物研究:体内实验报告》(ARRIVE)指南,对发表在中国期刊上的动物实验报告质量进行了回顾性评估.
结果:CNKI数据库,万方,VIP,和CBM从开始到2018年7月进行搜索。两名经过适当培训的审稿人独立筛选和提取文章。ARRIVE指南用于评估已发表的动物实验报告的质量。分析每个项目相对于其发布日期的依从率。共纳入4342项研究,其中73.0%被引用≤5次。只有29.0%(1261/4342)发表在中国科学引文数据库中列出的期刊上。结果表明,大约一半的子项目的达标率(51.3%,20/39)小于50%,其中65.0%(13/20)甚至不到10%。
结论:中国期刊动物实验报道质量不高。在2010年ARRIVE准则发布之后,其大多数要求的遵守率在一定程度上有所提高。然而,对实验动物的伦理和福利的关注较少,以及方法中的一些特定项目,Results,和讨论部分仍然没有足够详细地报告。因此,有必要推广《到达指南》,倡导研究人员在未来坚持他们,特别是在专业期刊上推广使用该指南,实施,促进动物实验的报道,最终提高他们的质量。
BACKGROUND: In view of the inadequacy and incompleteness of currently-reported animal experiments and their overall poor quality, we retrospectively evaluated the reporting quality of animal experiments published in Chinese journals adhering to the Animal Research: Reporting of In Vivo Experiments (ARRIVE)
guidelines.
RESULTS: The databases CNKI, WanFang, VIP, and CBM were searched from inception until July 2018. Two appropriately-trained reviewers screened and extracted articles independently. The ARRIVE
guidelines were used to assess the quality of the published reports of animal experiments. The compliance rate of every item was analyzed relative to their date of publication. A total of 4342 studies were included, of which 73.0% had been cited ≤5 times. Only 29.0% (1261/4342) were published in journals listed in the Chinese Science Citation Database. The results indicate that the compliance rate of approximately half of the sub-items (51.3%, 20/39) was less than 50%, of which 65.0% (13/20) was even less than 10%.
CONCLUSIONS: The reporting quality of animal experiments in Chinese journals is not at a high level. Following publication of the ARRIVE
guidelines in 2010, the compliance rate of the majority of its requirements has improved to some extent. However, less attention has been paid to the ethics and welfare of experimental animals, and a number of specific items in the Methods, Results, and Discussion sections continue to not be reported in sufficient detail. Therefore, it is necessary to popularize the ARRIVE
guidelines, advocate researchers to adhere to them in the future, and in particular promote the use of the
guidelines in specialized journals in order that the design, implementation, and reporting of animal experiments is promoted, to ultimately improve their quality.