目前没有足够的证据证明急性A型主动脉夹层患者入院时血尿酸与院内死亡率之间存在相关性。因此,本研究分析了急性A型主动脉夹层患者血尿酸与院内死亡的关系。2010年1月至2018年12月,共有1048例急性A型主动脉夹层患者参加了这项研究。自变量为入院时血尿酸,而因变量是住院死亡。研究的协变量包括患者年龄,性别,身体质量指数,吸烟状况,高血压,糖尿病,马凡氏综合征,二叶主动脉瓣,慢性肾功能不全,中风,动脉粥样硬化,时间介绍,收缩压,舒张压,主动脉直径,主动脉瓣反流,腹部血管受累,拱形血管参与,射血分数,实验室参数,症状,冠状动脉灌注不良,肠系膜灌注不良,脑灌注不良,低血压/休克,心脏压塞和手术状态。样本平均年龄为50.17±11.47岁,大约24.24%的参与者是女性。经过分析,发现急性A型主动脉夹层患者入院时血尿酸与院内死亡呈正相关(OR=1.04,95%CI1.02-1.06)。随后,在急性A型主动脉夹层患者的入院血清尿酸(260µmol/L点)与院内死亡率之间确定了非线性关系.拐点右侧(血清尿酸>260µmol/L)和左侧(血清尿酸≤260µmol/L)方面的效应大小和置信区间分别为1.04(1.02-1.05)和1.00(0.99-1.02),分别。此外,亚组分析表明血尿酸与住院死亡率之间存在稳定的关系,而不同亚组之间的相互作用差异不显著。总的来说,急性A型主动脉夹层患者入院时血尿酸与院内死亡率之间存在非线性相关性.当血清尿酸>260μmol/L时,与住院死亡率呈正相关.
There is currently insufficient evidence of correlation between on-admission serum uric acid and in-hospital mortality of patients with acute type A aortic dissection. Thus, this
study analysed the relation between serum uric acid and in-hospital deaths in patients with acute type A aortic dissection. A total of 1048 patients with acute type A aortic dissection participated in this
study between January 2010 and December 2018. The independent variable was on-admission serum uric acid, whilst the dependent variable was in-hospital deaths. The covariates of the
study included patient age, gender, body mass index, smoking status, hypertension, diabetes, Marfan syndrome, bicuspid aortic valve, chronic renal insufficiency, stroke, atherosclerosis, time to presentation, systolic blood pressure, diastolic blood pressure, aortic diameter, aortic regurgitation, abdominal vessel involvement, arch vessel involvement, ejection fraction value, laboratory parameters, symptom, coronary malperfusion, mesenteric malperfusion, cerebral malperfusion, hypotension/shock, cardiac tamponade and operation status. The mean age of the sample was 50.17 ± 11.47 years, with approximately 24.24% of the participants being female. After analysis, it was found that the admission serum uric acid of patients with acute type A aortic dissection was positively correlated with in-hospital death (OR = 1.04, 95% CI 1.02-1.06). Subsequently, a non-linear relationship was determined between admission serum uric acid (point 260 µmol/L) and in-hospital mortality for patients with acute type A aortic dissection. The effect sizes and confidence intervals of the right (serum uric acid > 260 µmol/L) and left (serum uric acid ≤ 260 µmol/L) aspects of the inflection point were 1.04 (1.02-1.05) and 1.00 (0.99-1.02), respectively. Furthermore, subgroup analysis indicated a stable relationship between serum uric acid and in-hospital mortality, whilst an insignificant difference was found for the interactions between different subgroups. Overall, a non-linear correlation was determined between admission serum uric acid and in-hospital mortality of patients with acute type A aortic dissection. When serum uric acid > 260 µmol/L, it showed a positive correlation with in-hospital mortality.