急危重症的特点是突发性,复杂性和不可预测性,这可能导致严重的不良预后,如休克或多器官衰竭。已经证实,醛代谢紊乱导致大量醛类物质积累的共同机制,毒性醛引起的细胞和组织损伤,各种紧急和危重疾病都存在器官功能障碍。然而,醛代谢紊乱理论的定义,醛的检测方法,醛代谢紊乱理论在指导急危重症早期治疗中的应用尚未系统化和规范化。因此,中华急诊医学会,中国医疗保健国际交流与促进协会胸痛分会,山东省医学会心肺复苏与体外生命支持多学科联合委员会组织了急诊和重症医学多学科专家,药房,和分子化学,等。,全面回顾国内外关于醛代谢紊乱在急危重症早期影响的基础和临床研究,并共同制定了《中国醛代谢紊乱专家共识》,指导急诊和重症医学的早期管理(2023年)。醛代谢紊乱的新共识旨在进一步提高急危重症的治疗水平,从而提出了一个新的,为危重患者提供安全可靠的治疗策略,提高危重患者的总体生存率。
Emergency and critical diseases is characterized by suddenness, complexity and unpredictability, which can lead to severe adverse prognosis such as shock or multiple organ failure. It has been confirmed that the common mechanism of aldehyde metabolism disorder leading to the accumulation of a large number of
aldehydes, injury of cells and tissues caused by toxic
aldehydes, and organ dysfunction existed in various emergency and critical diseases. However, the definition of the theory of aldehyde metabolism disorder, the detection methods of
aldehydes, and the application of the theory of aldehyde metabolism disorder in guiding the early treatment of emergency and critical diseases have not been systematized and standardized. Therefore, Chinese Society of Emergency Medicine, Chest Pain Branch of China International Exchange and Promotive Association for Medical and Health Care, and Multidisciplinary Joint Committee on Cardiopulmonary Resuscitation and Extracorporeal Life Support of Shandong Medical Association organized multidisciplinary experts in emergency and critical care medicine, pharmacy, and molecular chemistry, etc., to comprehensively review the basic and clinical research on the effect of aldehyde metabolism disorder in the early stage of emergency and critical diseases at home and abroad, and jointly formulated the Chinese experts
consensus on aldehyde metabolism disorder guided the early management of emergency and critical care medicine (2023). The novel and common
consensus on the aldehyde metabolism disorder aims to further improve the treatment level of the emergency and critical diseases, so as to put forward a new, safe and reliable treatment strategy for the critical patients, and improve the overall survival rate of the critical patients.