目标:已知许多因素会增加患乳腺癌的风险,比如年龄,家族史,初潮早和绝经晚是不可改变的。可改变的因素包括肥胖,使用更年期激素和母乳喂养。这项研究旨在评估TikurAnbessa专科医院女性患乳腺癌的危险因素。
方法:基于设施的病例对照研究。
方法:病例对照研究于2018年5月至2019年6月进行。共有230例病例和230名对照参与了研究。数据采用SPSS软件进行分析。基于多变量Logistic模型的分析控制潜在混杂因素的影响。计算发生乳腺癌可能性的OR和95%CI。
结果:40至49岁女性患乳腺癌的几率更高(校正OR(AOR):3.29,95%CI1.39至7.77),和失业(AOR:4.28,95%CI2.00至9.16)。关于生活方式的危险因素,食用固体油和使用木材或动物粪便作为燃料的女性患乳腺癌的几率明显更高。此外,绝经后妇女患乳腺癌的几率明显更高,曾接受过良性手术的女性和初潮早期(<12岁)的女性。另一方面,在有中等体力活动的女性中,乳腺癌的奇怪程度明显较低。
结论:这项研究表明,职业状况,固体油的消费,使用木材或动物粪便作为燃料来源,初潮早,绝经状态和既往良性乳腺手术与乳腺癌相关.另一方面,体力活动是保护因素。因此,有必要设计适当的干预措施,以教育女性改变生活方式或改变行为,以降低患乳腺癌的风险。
Many factors known to increase the risk of breast cancer, such as age, family history, early menarche and late menopause are not modifiable. Modifiable factors include obesity, use of menopausal hormones and breast feeding. This study aimed to assess risk factors associated with breast cancer among women at Tikur Anbessa Specialized Hospital.
Facility based
case-control study.
Case-control study was conducted from May 2018 to June 2019. A total of 230 cases and 230 controls participated in the study. Data were analysed using SPSS software. Multivariable logistic model based analysis was conducted to control the effect of potential confounding factors. ORs and 95% CI for the likelihood of developing breast cancer were calculated.
The odds of breast cancer was higher among women between 40 and 49 years (adjusted OR (AOR): 3.29, 95% CI 1.39 to 7.77), and being unemployed (AOR: 4.28, 95% CI 2.00 to 9.16). Regarding life style risk factors, women consuming solid oil and using wood or animal dung as source of fuel had significantly higher odds of breast cancer. In addition, the odds of breast cancer was significantly higher among postmenopausal women, women who had previous benign surgery and women with early menarche (<12 years). On the other hand, the odd of breast cancer was significantly lower among women who had moderate physical activities.
This study showed that occupational status, consumption of solid oil, and using wood or animal dung as source of fuel, early menarche, menopausal status and previous benign breast surgery were associated with breast cancer. On the other hand, physical activity was protective factor. Therefore, there is a need to design appropriate intervention to educate women about life style change or behaviour modification to decrease their breast cancer risk.