背景:牙齿移动的协调需要骨骼合成和吸收的平衡。维生素D,通过受体介导的作用,调节成骨细胞的分化和成熟,也诱导破骨细胞生成,保持这种平衡。
目的:分析维生素D对正畸牙齿移动的影响。
方法:通过七个电子数据库的系统搜索,对现有文献进行了全面探索。
方法:使用PICO格式建立纳入标准:使用固定矫治器(P)治疗的正畸患者,服用维生素D3(I),与适当的对照组(C)进行比较,以牙齿移动为主要结果和牙根吸收,锚固损失,龈沟液(GCF)体积,疼痛感知,和牙槽骨密度作为次要结果(O)。
方法:经过广泛的数据库搜索,共获得251篇文章。在使用系统评论和荟萃分析(PRISMA)声明的首选报告项目进行严格选择后,选择了六篇文章。随机对照试验(RCT)的严格评估涉及RoB2工具的细致应用。定量合成仅包含六篇文章的子集。
结果:在研究维生素D对OTM影响的荟萃分析中,维生素D组和对照组之间存在显著差异.具体来说,标准化平均差(SMD)为1.43,95%置信区间(CI)为0.691~2.169(P=.00154).对于根吸收,SMD记录为-0.51,95%CI为-3.051至2.031(P=.11).
结论:全身和局部施用维生素D可提高牙齿移动率。现有数据的不足阻碍了最终确定维生素D对牙根吸收程度的影响.解决这一难题需要未来的人类研究致力于调查维生素D在OTM和相关根吸收领域的影响,从而提供了一个明确的说明。
背景:Prospero-CRD42023491783。
BACKGROUND: Orchestration of tooth movement necessitates an equilibrium of bone synthesis and resorption. Vitamin D, through receptor-mediated actions, regulates the differentiation and maturation of osteoblasts and also induces osteoclastogenesis, maintaining this equilibrium.
OBJECTIVE: To analyze the impact of vitamin D in orthodontic tooth movement (OTM).
METHODS: A comprehensive exploration of the existing literature was conducted by systematic search through seven e-databases.
METHODS: The criteria for inclusion were established using the PICO format: Orthodontic patients treated with fixed appliance (P), administered with vitamin D3 (I), collated with appropriate control groups (C), with tooth movement as the primary outcome and root resorption, anchorage loss, gingival crevicular fluid (GCF) volume, pain perception, and alveolar bone density as the secondary outcome (O).
METHODS: After an extensive database search, 251 articles were obtained. Six articles were chosen following a stringent selection using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The critical appraisal of randomized control trials (RCTs) involved the meticulous application of the RoB 2 tool. The quantitative synthesis incorporated a subset of six articles only.
RESULTS: In the meta-analysis investigating the influence of vitamin D on OTM, a notable disparity was evident between the vitamin D and control groups. Specifically, the standardized mean difference (SMD) stood at 1.43, accompanied by a 95% confidence interval (CI) ranging from 0.691 to 2.169 (P = .00154). For root resorption, the SMD was recorded at -0.51, with a 95% CI spanning from -3.051 to 2.031 (P = .11).
CONCLUSIONS: The rate of tooth movement was enhanced by systemic and local administration of vitamin D. However, the inadequacy of available data is a hindrance in determining conclusively the impact of vitamin D on the extent of root resorption. The resolution of this quandary needs future human studies devoted toward investigating the influence of vitamin D in the realms of OTM and associated root resorption, thereby providing a definitive elucidation.
BACKGROUND: Prospero- CRD42023491783.