ZEB1反义RNA1(ZEB1-AS1)是一种RNA,其特征为长链非编码RNA(lncRNA)。这种lncRNA对其相关基因具有重要的调节作用,锌指E盒绑定同源盒1(ZEB1)。此外,ZEB1-AS1的作用已被批准在多种恶性肿瘤,如结直肠癌,乳腺癌,神经胶质瘤,肝细胞癌和胃癌。ZEB1-AS1充当许多microRNA的海绵,即miR-577,miR-335-5p,miR-101,miR-505-3p,miR-455-3p,miR-205,miR-23a,miR-365a-3p,miR-302b,miR-299-3p,miR-133a-3p,miR-200a,miR-200c,miR-342-3p,miR-214、miR-149-3p和miR-1224-5p。除了恶性疾病,ZEB1-AS1在糖尿病肾病等非恶性疾病中具有功能作用,糖尿病肺,关节硬化,沙眼衣原体感染,肺纤维化和缺血性中风。本文概述了ZEB1-AS1在多种疾病中的不同分子机制,并强调了其在其发病机理中的重要性。
ZEB1 Antisense RNA 1 (ZEB1-AS1) is a type of RNA characterized as long non-coding RNA (lncRNA). This lncRNA has important regulatory roles on its related gene, Zinc Finger E-Box Binding Homeobox 1 (ZEB1). In addition, role of ZEB1-AS1 has been approved in diverse malignancies such as colorectal cancer, breast cancer, glioma, hepatocellular carcinoma and gastric cancer. ZEB1-AS1 serves as a sponge for a number of microRNAs, namely miR-577, miR-335-5p, miR-101, miR-505-3p, miR-455-3p, miR-205, miR-23a, miR-365a-3p, miR-302b, miR-299-3p, miR-133a-3p, miR-200a, miR-200c, miR-342-3p, miR-214, miR-149-3p and miR-1224-5p. In addition to malignant conditions, ZEB1-AS1 has functional role in non-malignant conditions like diabetic nephropathy, diabetic lung, arthrosclerosis, Chlamydia trachomatis infection, pulmonary fibrosis and ischemic stroke. This
review outlines different molecular mechanisms of ZEB1-AS1 in a variety of disorders and highlights its importance in their pathogenesis.