未经证实:DNA修复和维持基因的遗传多态性导致突变和失调的生长激素,这与癌症有关。除了确定的致癌物如烟草,特定的遗传多态性与个体患口腔癌的风险相对应。本研究旨在鉴定Karad患有和不患有口腔癌的受试者的遗传多态性差异,印度。
UNASSIGNED:本研究的目的是表征与氧化应激有关的口腔癌相关基因的遗传多态性,致癌物解毒,DNA修复
UNASSIGNED:对150名受试者进行了基于医院的病例对照,分为病例(n=75)和对照(n=75)。基于聚合酶链式反应的限制性片段长度多态性测定被用来对所选择的DNA修复的多态性进行基因分型,解毒,和氧化应激相关基因。
未经评估:在病例组中,在DNA修复集中,基因-1(XRCC1),基因3(XRCC3),着色性干皮病D组基因(XPD),和人8-氧鸟嘌呤DNA糖基化酶(hOGG1)表现出明显的遗传多态性。同样,致癌物解毒基因-N-乙酰转移酶的遗传多态性,注意到GSTP1和氧化应激相关基因过氧化氢酶。
UNASSIGNED:Cramer的V/比值比用于评估遗传风险因素与口腔癌的关联。
未经授权:XRCC1,XRCC3,XPD,与对照组相比,hOGG1基因对口腔癌的易感性更高。这些信息可能是口腔肿瘤学中用于一级预防和干预的有用的新标记。
UNASSIGNED: The genetic polymorphism in the DNA repair and maintenance genes leads to mutations and deregulated growth hormones which have implications in cancer. Apart from identified carcinogens such as tobacco, specific genetic polymorphisms correspond to an individual\'s risk of oral cancer. The current study aims at identification of differences in genetic polymorphisms in subjects with and without oral cancer in Karad, India.
UNASSIGNED: The aim of the study was to characterize genetic polymorphisms in oral cancer-related genes pertaining to oxidative stress, carcinogen detoxifying, and DNA repair.
UNASSIGNED: A hospital-based
case-control was conducted with 150 subjects sorted into cases (n = 75) and controls (n = 75). The polymerase chain reaction-based restriction fragment length polymorphism assay was used to genotype the polymorphisms of selected DNA repair, detoxifying, and oxidative stress-related genes.
UNASSIGNED: In the cases group, among the DNA repair set, Gene-1 (XRCC1), Gene-3 (XRCC3), Xeroderma Pigmentosum Group-D gene (XPD), and human 8-oxoguanine DNA glycosylase (hOGG1) showed significant genetic polymorphism. Similarly, the genetic polymorphism in the carcinogen detoxifying genes-n-acetyl transferase, GSTP1, and oxidative stress-related gene catalase were noted.
UNASSIGNED: The Cramer\'s V/odds ratio was applied to estimate the association of genetic risk factors with oral cancer.
UNASSIGNED: The polymorphisms of XRCC1, XRCC3, XPD, and hOGG1 genes were associated with a higher susceptibility to oral cancer as compared to controls. This information may be a useful novel marker in oral oncology for primary prevention and intervention.