虾青素(ASX)是一种在几种微生物和海产品中发现的天然类胡萝卜素化合物。它可能对多囊卵巢综合征(PCOS)患者具有许多治疗益处。这项研究的目的是研究ASX对血脂的影响,胰岛素抵抗(IR),血压(BP),PCOS不育患者的氧化应激(OS)水平。总的来说,58名诊断为PCOS的不孕妇女参加了这项三盲随机临床试验。他们被随机分配到两组,服用安慰剂或ASX(2×6mg/天)8周。在干预前后收集患者的血清样本。空腹胰岛素(FI),空腹血糖(FBS),OS标记(丙二醛[MDA],超氧化物歧化酶[SOD],和总抗氧化能力[TAC]),在血清中评估血脂谱。此外,根据相关公式,计算了与IR相关的几个指标。在研究开始和结束时还评估了BP。ASX消费8周后,观察到空腹血糖显着降低,HOMA-IR,FI,MDA,低密度脂蛋白胆固醇,和TC/HDL-C。相反,ASX显著增加了TAC,HDL-C,还有QUICKI.在调整年龄基线值的分析后,身体质量指数,和生化参数,获得QUICKI和FI的非显著值,其他发现没有变化。总的来说,ASX似乎是一种有效且安全的补充剂,可以缓解胰岛素代谢,脂质轮廓参数,不育PCOS患者的OS。
Astaxanthin (ASX) is a natural carotenoid compound found in several of microorganisms and seafood. It may have numerous therapeutic benefits for polycystic ovarian syndrome (PCOS) patients. The aim of this
study was to investigate the effect of ASX on lipid profile, insulin resistance (IR), blood pressure (BP), and oxidative stress (OS) levels in infertile PCOS patients. Overall, 58 infertile women with diagnosed PCOS participated in this triple-blind randomized clinical
trial. They were randomly assigned to two groups, taking either a placebo or ASX (2 × 6 mg/day) for 8 weeks. Blood serum samples were collected from patients before and after the intervention. Fasting Insulin (FI), fasting blood glucose (FBS), OS markers (malondialdehyde [MDA], superoxide dismutase [SOD], and total antioxidant capacity [TAC]), and lipid profiles were evaluated in serum. Moreover, based on the relevant formula, several indices associated with IR were calculated. BP was also assessed at the start and end of the
study. After 8 weeks of ASX consumption, a significant reduction was observed in fasting blood sugar, HOMA-IR, FI, MDA, low-density lipoprotein-cholesterol, and TC/HDL-C. Conversely, ASX significantly increased TAC, HDL-C, and QUICKI. After adjusting the analysis for the baseline values of age, body mass index, and biochemical parameters, non-significant values were obtained for QUICKI and FI, along with no changes in other findings. Overall, ASX appears to be an effective and safe supplement that alleviates insulin metabolism, lipid profile parameters, and OS in infertile PCOS patients.