目的:X连锁低磷酸盐血症(XLH)是一种罕见的遗传性疾病,会干扰骨骼和牙齿的矿化。它还会影响颅面生长,XLH患者通常需要正畸治疗。这项研究的目的是描述XLH儿童在正畸治疗期间与接受类似正畸治疗的匹配对照组相比的牙齿健康变化。
方法:对于这项回顾性病例对照研究,我们纳入了所有16岁以下被诊断患有XLH的个体,2016年至2022年在我们中心进行正畸治疗,并与没有慢性或遗传疾病的患者配对。有关其错牙合的临床和放射学参数,分析了颅面差异及其正畸治疗的特点和医源性效果。
结果:15名XLH患者(平均年龄:11.3±2.1),与15名对照患者配对。在XLH患者中成功进行了正畸治疗,其持续时间略短,医源性效果与对照组相似。除了在正畸牙齿移动期间和之后发生牙脓肿。XLH患者没有显示比对照组更多的复发。
结论:尽管存在XLH的口腔表现,如自发性脓肿,XLH患者可以接受正畸治疗,没有明显的附加医源性作用。
OBJECTIVE: X-linked hypophosphatemia (
XLH) is a rare genetic disease that disturbs bone and teeth mineralization. It also affects craniofacial growth and patients with
XLH often require orthodontic treatment. The aim of this study was to describe changes in the dental health of
XLH children during orthodontic treatment compared with those in matched controls undergoing similar orthodontic procedures.
METHODS: For this retrospective
case-control study, we included all individuals less than 16 years old diagnosed with XLH, orthodontically treated in our centre from 2016 to 2022 and pair-matched them to patients with no chronic or genetic conditions. Clinical and radiological parameters concerning their malocclusion, craniofacial discrepancy and the characteristics and iatrogenic effects of their orthodontic treatment were analysed.
RESULTS: Fifteen XLH patients (mean age: 11.3 ± 2.1), pair-matched to 15 control patients were included. Orthodontic treatment was successfully conducted in XLH patients with slightly shorter duration and similar iatrogenic effects as in the control group, except for the occurrence of dental abscess during and after orthodontic tooth movement.
XLH patients did not show more relapse than the controls.
CONCLUSIONS: Despite the presence of oral manifestations of XLH such as spontaneous abscesses, XLH patients can undergo orthodontic treatment with no obvious additional iatrogenic effects.