Wnt/β-catenin signalling pathway

Wnt / β - catenin 信号通路
  • 文章类型: Systematic Review
    背景:半乳糖凝集素是β-半乳糖苷结合蛋白。半乳糖凝集素-4已显示对癌症进展/转移的影响,尤其是消化系统的癌症。这可以归因于细胞膜分子糖基化模式的改变,这是肿瘤发生的特征。本文旨在系统综述半乳糖凝集素-4在不同癌症中的作用及其在疾病进展中的作用。
    方法:该研究是根据系统评价和荟萃分析(PRISMA)指南的首选报告项目设计的。PubMed,Scopus,WebofScience,和ScienceDirect用于搜索关键词“半乳糖凝集素-4和癌症”的相关文献,“半乳糖凝集素-4”,\"LGALS4\",和“LGALS4和癌症”。研究选择的纳入标准是全文文章的可用性,英语文章和与当前主题相关的文章,即,半乳糖凝集素-4和癌症。排除标准是调查其他疾病状况的研究,与癌症或半乳糖凝集素-4和偏倚结局无关的干预措施。
    结果:从数据库中删除重复的文章后,共检索到73篇文章,其中40项研究纳入了符合纳入标准的审查中,包括低到中等的偏差。其中包括23项消化系统研究,5在生殖系统中,4在呼吸系统,和2在脑癌和尿路上皮癌。
    结论:在不同的癌症分期和类型中观察到半乳糖凝集素-4的差异表达。此外,发现半乳糖凝集素-4调节疾病进展。荟萃分析和综合机理研究,关于半乳糖凝集素-4生物学的不同方面,可以给出统计驱动的相关性,阐明半乳糖凝集素-4在癌症中的多方面作用。
    BACKGROUND: Galectins are β-galactoside-binding proteins. Galectin-4 has shown an effect on cancer progression/metastasis, especially in cancers of the digestive system. This can be attributed to altered glycosylation pattern of cell membrane molecules, which is a characteristic attribute of oncogenesis. The aim of this paper is to systematically review galectin-4 in different cancers and its role in disease progression.
    METHODS: The study was designed on the basis of Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines. PubMed, Scopus, Web of Science, and Science Direct were used to search relevant literature with keywords \"galectin-4 AND cancer\", \"galectin-4\", \"LGALS4\", and \"LGALS4 AND cancer\". Inclusion criteria for study selection were availability of full-text articles, articles in English language and articles relevant to current topic, that is, galectin-4 and cancer. Exclusion criteria were studies that investigated other disease conditions, interventions unrelated to cancer or galectin-4 and bias outcome.
    RESULTS: A total of 73 articles were retrieved after removing duplication from databases, out of which 40 studies were included in the review that followed the inclusion criteria, including low to moderate bias. These included 23 studies in digestive system, 5 in reproductive system, 4 in respiratory system, and 2 in brain and urothelial cancers.
    CONCLUSIONS: A differential expression of galectin-4 was observed in different cancer stages/ and types. Furthermore, galectin-4 was found to modulate disease progression. A meta-analysis and comprehensive mechanistic studies, pertaining to different aspects of galectin-4 biology, could give statistically driven correlations, elucidating multifaceted role of galectin-4 in cancer.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

公众号