在单个患者中发生多种原发性恶性肿瘤相对罕见。我们在这里报道了一个71岁的男性患有三个原发性肺癌肿瘤的病例,肝内胆管癌,前列腺癌,并对多原发肿瘤在基因水平上发展的机制进行了初步研究。由于病人病情的晚期,大肿瘤负荷,和糟糕的身体状况,病人只活了几个月。在本文介绍的情况下,胆管癌,肺癌,同时发现前列腺癌,和致病部位无关。对病理组织进行全外显子组测序,以探索在遗传水平上可能导致多原发癌的机制。在这种情况下发现了几种基因突变。它们涉及细胞增殖,细胞周期调节,遗传稳定性,新陈代谢,细胞入侵,血管生成,细胞凋亡,和其他途径。初步推测多原发肿瘤的发病机制与促抑瘤通路的异常有关。
The occurrence of multiple primary malignancies in a single patient has been relatively rare. We report here the
case of a 71-year-old man with three primary tumors of lung cancer, intrahepatic cholangiocarcinoma, and prostate cancer, and a preliminary study of the mechanisms by which multiple primary tumors develop at the genetic level. Because of the late stage of the patient\'s condition, large tumor burden, and poor physical status, the patient survived only a few months. In the
case presented herein, cholangiocarcinoma, lung cancer, and prostate cancer were found simultaneously, and the pathogenic sites are not related. Whole-exome sequencing was performed on the pathological tissues to explore the mechanism that may underlie multiple primary cancers at the genetic level. Several gene mutations were found in this
case. They involved cell proliferation, cell cycle regulation, genetic stability, metabolism, cell invasion, angiogenesis, cell apoptosis, and other pathways. It can be preliminarily inferred that the mechanism underlying multiple primary tumors is related to the abnormality of tumor-promoting and suppressing pathways.