全球范围内,冠状动脉疾病(CAD)仍然是死亡的主要原因之一,发达国家和包括孟加拉国在内的欠发达国家(LEDC)。饮食在动脉粥样硬化和冠状动脉疾病(CAD)的发病过程中起着关键作用。这项研究的目的是评估患有CAD的心脏病病例与匹配对照的饮食习惯。
遵守赫尔辛基的道德规范,经书面同意,这项病例对照研究是在210名受试者中进行的:105名CAD住院患者(选自LabAid心脏和专科医院)和105名来自当地城市社区的健康受试者,他们的体重指数(BMI:≥18.5和27社会人口统计学状况,详细的饮食模式和血压水平被记录,测量人体测量指数,和血清生物化学(完整的脂质分布)测试/分析的病例和对照。在SPS/WindowsV.21.0上使用适当的统计工具(t检验/条件逻辑回归)分析所有视觉重新检查的数据。
几乎一半(45%)的CAD患者有高甘油三酯血症和较高水平的低密度脂蛋白,BMA显著升高(p=0.001),腰围,男性患者的腰臀比(分别为p=0.005和p=0.020)高于同龄人对照组。血脂谱,糖浓度,CAD患者的血压水平显示高于临床定义的临界值,这是CAD的既定危险因素。作为食用垃圾食品的危险因素的赔率(CI95%){OR=5.49(2.25-13.38)},鸡{OR=4.54(1.89-10.9)最多,其次是牛肉{OR=2.68(1.19-4.98)},鸡蛋{OR=2.38(1.14-10.92)},fish{OR=2.81(1.31-6.04)},和蔬菜{0R=.968(0.510-1.839)}。然而,无脂牛奶,酥油/黄油,凝乳/酸奶,水果的ORs较低,没有或有较小的CAD风险。
CAD患者的饮食习惯(具有较高的BMI水平和血液生化指标)统计显示,食用垃圾食品,肉,鸡蛋风险更大,水果,无脂牛奶,酸奶,蔬菜遗骸对CAD有保护作用。
Globally, coronary artery disease (CAD) remains one of the leading causes of death, both in developed and less economically developed countries (LEDC) including Bangladesh. Diet plays a key role in the pathogenesis processes of atherosclerosis and coronary artery disease (CAD). The purpose of this study was to assess the dietary habit of heart disease cases that had CAD against matched controls.
Complying Helsinki ethical norms, with written consent, this
case-control study was performed among 210 subjects: 105 CAD-hospitalized patients (selected from Lab Aid Cardiac and Specialized Hospitals) and 105 healthy subjects from local urban communities having their body mass index (BMI: ranging between ≥18.5 and 27 socio-demographic status, detailed-dietary patterns and blood pressure levels were recorded, anthropometric indices measured, and serum biochemistry (complete lipid profile) tested/analyzed for both the cases and controls. All visually re-checked data were analyzed using appropriate statistical tools (t test/conditional-logistic regressions) on SPS/Windows V.21.0.
Almost half (45%) CAD patients had hypertriglyceridemia and higher levels of low-density lipoprotein, significantly higher BMA (p=0.001), waist circumference, and waist to hip ratio in male patients (p=0.005 and p=0.020, respectively) than their peer controls. Serum lipid profiles, sugar concentrations, and blood pressure levels of CAD patients revealed higher levels than clinically defined cut-off values as established risk factors for CAD. Odds ratios (CI 95%) as risk factors for consuming junk food {OR=5.49 (2.25-13.38)}, chicken {OR=4.54 (1.89-10.9) was the most, followed by beef {OR=2.68 (1.19-4.98)}, eggs {OR=2.38 (1.14-10.92)}, fish {OR=2.81 (1.31-6.04)}, and vegetables {0R=.968 (0.510-1.839)}. However, fat-free milk, ghee/butter oil, curd/yogurt, and fruits had lower ORs revealing no or less risks for CAD.
Food habits of CAD patients (with higher BMI level and biochemical indicators of the blood) statistically revealed that consuming junk food, meat, and eggs being riskier, fruits, fat-free milk, yogurt, and vegetable remains have protective effects on CAD.