WD重复结构域6(WDR6),一种新的人类WD重复基因,编码WD重复蛋白家族的成员,到目前为止,它的致瘤作用很少被报道。
我们的研究使用了Oncomine,TIMER2.0,GEPIA2,Kaplan-Meier绘图仪,PrognoScan,和TISIDB工具来分析泛癌之间的差异表达,尤其是肺癌,和相应的正常组织,并进一步探讨WDR6表达在预后和免疫学方面的作用。
我们的结果显示,WDR6在肺鳞癌组织中的表达低于正常组织,但WDR6在肺腺癌中的表达与临床分期明显相关。总生存率,第一次进步,进展后生存,WDR6高表达组肺癌患者的无复发生存期长于低表达组。我们发现WDR6的表达与免疫分子显着相关,包括免疫调节剂,淋巴细胞,和肺癌中的趋化因子。
WDR6可作为肺癌的预后标志物,与免疫细胞浸润显著相关。
WD repeat domain 6 (WDR6), a novel human WD-repeat gene, encodes a member of the WD repeat protein family, and its tumorigenic effect has rarely been reported so far.
Our
study used Oncomine, TIMER2.0, GEPIA2, Kaplan-Meier plotter, PrognoScan, and TISIDB tools to analyze the differential expression between pan-cancer, especially lung cancer, and corresponding normal tissue, and further explore the prognostic and immunological role of WDR6 expression.
Our results showed WDR6 was lower expressed in lung squamous cell carcinoma than in normal tissue, but WDR6 expression was correlated obviously with clinical stage in Lung adenocarcinoma. The overall survival, first progression, postprogression survival, and Relapse-free survival of lung cancer patients were longer in the WDR6 high-expression group than in the low-expression group. We found the expression of WDR6 significantly correlated with immune molecules, including immunomodulators, lymphocytes, and chemokines in lung cancer.
WDR6 can be used as a prognostic marker for lung cancer and is significantly associated with immune cell infiltration.