肺炎克雷伯菌是一种机会性病原体,可引起多种感染,主要在住院或免疫受损的个体中。肺炎克雷伯氏菌新出现的毒力和多重耐药克隆的传播是全世界关注的问题,其鉴定对于控制这些菌株至关重要,尤其是在医院中。本文报道了与多重耐药肺炎克雷伯菌菌株相关的数据,与马瑙斯市的住院病人隔离,巴西,携带毒力和抗菌素抗性基因,包括属于克隆组(CG)258的高风险国际克隆。从马瑙斯市四家医院收治的不同患者中分离出的21种菌株,位于亚马逊州,对巴西北部(亚马逊雨林地区)进行了评估。大多数菌株(61.9%n=13)被归类为多重耐药(MDR),5株(23.8%)为广泛耐药(XDR)。在这些菌株中发现了几种毒力和抗微生物药物抗性基因,并且有8个菌株(38.1%)呈现高粘膜粘性表型。MLST分析表明菌株之间的STs具有很大的多样性,总共12个不同的ST(ST11、ST23、ST198、ST277、ST307、ST340、ST378、ST462、ST502、ST3991、ST3993和ST5209)。其中三个(ST11、ST23和ST340)属于CG258。
Klebsiella pneumoniae is an opportunistic pathogen that can cause several infections, mainly in hospitalised or immunocompromised individuals. The spread of K. pneumoniae emerging virulent and multidrug-resistant clones is a worldwide concern and its identification is crucial to control these strains especially in hospitals. This article reports data related to multi-resistant K. pneumoniae strains, isolated from inpatients in the city of Manaus, Brazil, harbouring virulence and antimicrobial-resistance genes, including high-risk international clones belonging to clonal group (CG) 258. Twenty-one strains isolated from different patients admitted to four hospitals in the city of Manaus, located in the state of Amazonas, Northern Brazil (Amazon Rainforest region) were evaluated. The majority of strains (61.9% n = 13) were classified as multidrug-resistant (MDR), and five strains (23.8%) as extensively drug-resistant (XDR). Several virulence and antimicrobial-resistance genes were found among the strains and eight strains (38.1%) presented the hyper-mucoviscous phenotype. MLST analysis demonstrated a great diversity of STs among the strains, totaling 12 different STs (ST11, ST23, ST198, ST277, ST307, ST340, ST378, ST462, ST502, ST3991, ST3993 and ST5209). Three of these (ST11, ST23 and ST340) belong to CG258.