詹姆斯敦峡谷病毒(JCV)是加利福尼亚血清群中的一种蚊子直鼻病毒,在加拿大和美国各地传播。大多数JCV暴露导致无症状感染或轻度发热疾病,但是JCV也会引起神经系统疾病,如脑膜炎和脑炎。我们描述了不列颠哥伦比亚省人群中一系列确诊的JCV介导的神经侵袭性疾病,艾伯塔省,魁北克,和新斯科舍省,加拿大,2011-2016年。我们强调案例定义,流行病学,独特的特征和临床表现,疾病季节性,以及这些案件的结果。其中两名患者(来自魁北克和新斯科舍省)可能在前往美国东北地区的旅行中感染了JCV。该病例系列共同证明了JCV的广泛分布,并表明需要提高对JCV的认识,JCV是蚊子季节脑膜炎/脑膜脑炎的根本原因。
Jamestown Canyon virus (JCV) is a mosquitoborne orthobunyavirus in the California serogroup that circulates throughout Canada and the United States. Most JCV exposures result in asymptomatic infection or a mild febrile illness, but JCV can also cause neurologic diseases, such as meningitis and encephalitis. We describe a
case series of confirmed JCV-mediated neuroinvasive disease among persons from the provinces of British Columbia, Alberta, Quebec, and Nova Scotia, Canada, during 2011-2016. We highlight the
case definitions, epidemiology, unique features and clinical manifestations, disease seasonality, and outcomes for those cases. Two of the patients (from Quebec and Nova Scotia) might have acquired JCV infections during travel to the northeastern region of the United States. This
case series collectively demonstrates JCV\'s wide distribution and indicates the need for increased awareness of JCV as the underlying cause of meningitis/meningoencephalitis during mosquito season.