根据世界卫生组织,83,339例实验室确诊病例,包括72人死亡,天痘(以前称为猴痘),截至2022年12月20日,已在全球110个地点报告,使该疾病成为公共卫生问题。大多数病例(56,171,67.4%)来自北美国家。关于当前水痘疫情中疫苗有效性的数据有限。然而,已预测改良的牛痘病毒(天花疫苗)可以预防或减轻水痘感染的严重程度。本研究的系统评价和荟萃分析旨在通过报道的随机临床试验来评估改良牛痘疫苗的安全性和有效性。遵循Cochrane合作组织和PRISMA的指导方针,多个数据库,包括PubMed,PLOSONE,谷歌学者,英国医学杂志,搜索了美国国家医学图书馆。在最初确定的13,294篇研究文章中,在去除重复项后筛选187个。根据纳入和排除标准,荟萃分析包括10项研究,共7430例患者.三名研究人员独立评估了纳入研究中的偏倚风险。汇总结果表明,与未接种痘苗的组相比,接种痘苗的组的副作用较少(比值比:1.66;95%CI:1.07-2.57;p=0.03)。总的来说,改良的牛痘已被证明是安全和有效的牛痘幼稚和以前暴露的群体,在先前暴露的组中具有更高的疗效。
According to the World Health Organization, 83,339 laboratory-confirmed cases, including 72 deaths, of mpox (formerly known as monkeypox), have been reported from 110 locations globally as of 20 December 2022, making the disease a public health concern. Most of the cases (56,171, 67.4%) were reported from countries in North America. Limited data on vaccine effectiveness in the current mpox outbreak are available. However, the modified
vaccinia virus (smallpox vaccine) has been predicted to prevent or reduce the severity of the mpox infection. The present study of systematic
review and meta-analysis aimed to evaluate the modified
vaccinia vaccine\'s safety and efficacy on mpox by using reported randomized clinical trials. Following guidelines from the Cochrane Collaboration and PRISMA, multiple databases including PubMed, PLOS ONE, Google Scholar, British Medical Journal, and the U. S. National Library of Medicine were searched. Out of 13,294 research articles initially identified, 187 were screened after removing duplicates. Following the inclusion and exclusion criteria, the meta-analysis included ten studies with 7430 patients. Three researchers independently assessed the risk of bias in the included study. The pooled results suggest that the
vaccinia-exposed group had fewer side effects when compared to the
vaccinia naïve group (odds ratio: 1.66; 95% CI: 1.07-2.57; p = 0.03). Overall, the modified
vaccinia has proven safe and effective in both
vaccinia naïve and previously exposed groups, with higher efficacy in the previously exposed groups.