背景:特纳综合征(TS),女性最常见的染色体异常之一,常导致成人心血管和代谢并发症。关于儿科年龄的信息很少。这项研究旨在比较TS儿童和健康对照中心脏代谢危险因素的存在。
方法:这是一项横断面研究,将TS患者与年龄匹配的健康对照进行比较,关于心脏代谢风险因素,包括血脂,空腹血糖,胰岛素抵抗,身体成分,身体质量指数,血压,颈动脉内膜中层厚度(cIMT)。
结果:我们纳入了9名TS患者和9名对照,中位年龄为13岁(9-14岁)。3名TS患者和3名对照处于青春期前。所有TS患者均接受生长激素治疗(GHT),中位治疗6年(3-10年);4例患者接受了雌二醇治疗。TS患者和对照组在体重指数(BMI)方面没有发现统计学上的显着差异,胆固醇水平,和胰岛素抵抗。以体表面积为指标的cIMT在TS患者和对照组之间没有显着差异(分别为0.37vs0.35mm/m2,p=0.605)。TS患者的体脂水平较低(7.2%vs34.9%,p=0.004)。另一方面,TS患者的收缩压(z评分1.04vs-0.08,p=0.001)和舒张压(z评分1.08vs0.33,p=0.031)血压(BP),天冬氨酸(AST)和丙氨酸(ALT)转氨酶水平(26vs20U/L,p=0.008和19vs14U/L,分别为p=0.004)。
结论:TS患者,全部提交给GHT,与对照组相比,身体脂肪水平较低,尽管BMI相似。尽管我们发现两组之间的cIMT没有差异,患有TS的年轻女孩的BP和转氨酶水平较高。早期人体测量,心血管,对TS患者进行分析监测对于检测异常和预防进一步的并发症至关重要。
BACKGROUND: Turner syndrome (TS), one of the most common chromosomal abnormalities in females, often results in adult cardiovascular and metabolic complications. Information on pediatric age is scarce. This
study aimed to compare the presence of cardiometabolic risk factors in children with TS and healthy controls.
METHODS: This is a cross-sectional
study comparing patients with TS to age-matched healthy controls, regarding cardiometabolic risk factors including lipid profile, fasting glucose, insulin resistance, body composition, body mass index, blood pressure, and carotid intima-media thickness (cIMT).
RESULTS: We included nine TS patients and nine controls with a median age of 13 years (9-14 years). Three TS patients and three controls were prepubertal. All TS patients received growth hormone treatment (GHT), median treatment of six years (3-10 years); four patients underwent treatment with estradiol. No statistically significant differences were detected between TS patients and controls regarding body mass index (BMI), cholesterol levels, and insulin resistance. cIMT indexed to body surface area showed no significant differences between TS patients and controls (0.37 vs 0.35 mm/m2, respectively, p=0.605). TS patients had lower body fat levels (7.2% vs 34.9%, p=0.004). On the other hand, TS patients had higher levels of systolic (z-score 1.04 vs -0.08, p=0.001) and diastolic (z-score 1.08 vs 0.33, p=0.031) blood pressure (BP) and aspartate (AST) and alanine (ALT) aminotransferase levels (26 vs 20 U/L, p=0.008 and 19 vs 14 U/L, p=0.004, respectively).
CONCLUSIONS: Patients with TS, all submitted to GHT, had lower body fat levels compared with controls, despite similar BMI. Although we found no differences in cIMT between the two groups, young girls with TS had higher BP and transaminase levels. Early anthropometric, cardiovascular, and analytical monitoring of patients with TS is essential to detect abnormalities and prevent further complications.