以纳米技术为基础的癌症治疗受到了相当多的关注,这些治疗通常使用药物负载的纳米粒子（NPs）来靶向和破坏癌细胞。纳米技术结合光动力疗法（PDT）已在癌症治疗中显示出积极的结果。结合纳米技术和PDT在靶向转移性癌细胞方面是有效的。纳米技术还可以通过在分子水平上靶向细胞来提高PDT的有效性。基于树枝状聚合物的纳米缀合物（DBNs）是高度稳定和生物相容性的，使它们适用于药物输送应用。此外，DBN中的超支化结构具有负载疏水化合物的能力，如光敏剂（PSs）和化疗药物，并将它们有效地传递给肿瘤细胞。这篇综述主要集中在DBN及其在癌症治疗中的潜在应用。我们讨论化学设计，作用机制,以及DBN在肿瘤转移中的靶向效率，细胞内运输在癌症治疗中，和DBNs的生物相容性，生物降解性和清除性能。总的来说,这项研究将为DBNs和PDT在癌症治疗中的应用提供最新见解.
DBNs在癌症-PDT中的细胞内旅程完善了靶向治疗，增强功效。PDT中的DBN用于肿瘤转移：靶向和药物释放机制。DBN的生物相容性，对生物降解性和清除率进行了彻底探索。
Nanotechnology-based cancer treatment has received considerable attention, and these treatments generally use drug-loaded nanoparticles (NPs) to target and destroy cancer cells. Nanotechnology combined with photodynamic therapy (PDT) has demonstrated positive outcomes in cancer therapy. Combining nanotechnology and PDT is effective in targeting metastatic cancer cells. Nanotechnology can also increase the effectiveness of PDT by targeting cells at a molecular level. Dendrimer-based nanoconjugates (DBNs) are highly stable and biocompatible, making them suitable for drug delivery applications. Moreover, the hyperbranched structures in DBNs have the capacity to load hydrophobic compounds, such as photosensitizers (PSs) and chemotherapy drugs, and deliver them efficiently to tumour cells. This
review primarily focuses on DBNs and their potential applications in cancer treatment. We discuss the chemical design, mechanism of action, and targeting efficiency of DBNs in tumour metastasis, intracellular trafficking in cancer treatment, and DBNs\' biocompatibility, biodegradability and clearance properties. Overall, this study will provide the most recent insights into the application of DBNs and PDT in cancer therapy.
DBNs’ intracellular journey in cancer-PDT refines targeted therapy, boosting efficacy.DBN in PDT for tumour metastasis: targeting and drug release mechanisms.DBNs’ biocompatibility, biodegradability and clearance were explored thoroughly.
