■程序性细胞死亡配体1(PD-L1)表达和肿瘤浸润淋巴细胞(TIL)在高级别浆液性卵巢癌(HGSOC)中的预后价值仍然是该研究领域的一个有争议的话题。为了全面评估PD-L1和TILs在这种特定的卵巢癌亚型中的重要性,我们进行了荟萃分析.
■我们对PubMed进行了全面搜索,Embase,Scopus,WebofScience,和Cochrane图书馆数据库截至2022年12月25日。PD-L1,TIL,和生存结果使用组合风险比(HRs)及其相应的95%置信区间(CIs)进行评估.
■这项荟萃分析包括11项试验,共1746例。结果表明,肿瘤细胞(TC)中PD-L1的表达与总生存期之间没有显着关联(OS,HR=0.76,95%CI:0.52-1.09,p=0.136)或无进展生存期(PFS,HR=0.71,95%CI:0.4-1.24,p=0.230)。然而,免疫细胞(IC)中PD-L1表达与OS之间存在相关性(HR=0.73,95%CI:0.55-0.97,p=0.031).此外,发现CD8和PD-1TIL的存在显着提高OS(HR=0.70,95%CI=0.55-0.87,p=0.002;HR=0.57,95%CI=0.40-0.80,p=0.001)和PFS(HR=0.62,95%CI=0.41-0.92,p=0.019;HR=0.52,95%CI=2,p=0.35,p=而CD3+和CD4+TIL的存在与OS呈正相关(HR=0.50,95%CI=0.29-0.87,p=0.014;HR=0.55,95%CI=0.34-0.91,p=0.020).
■这项研究表明,IC衍生的PD-L1与生存率呈正相关,而TCs衍生的PD-L1与预后无显著相关性。这些结果突出了研究IC中PD-L1表达作为预后预测因子的重要性。此外,发现TIL的存在显着提高了患者的生存率,提示TIL可能是一种有价值的预后生物标志物。
■https://www.crd.约克。AC.英国/普华永道/,标识符CRD42022366411。
UNASSIGNED: The prognostic value of programmed cell death ligand 1 (PD-L1) expression and tumor-infiltrating lymphocytes (TILs) in high-grade serous ovarian cancer (HGSOC) remains a controversial topic in the research field. To comprehensively assess the importance of PD-L1 and TILs in this particular subtype of ovarian cancer, we performed a meta-analysis.
UNASSIGNED: We conducted a comprehensive search of PubMed, Embase, Scopus, Web of Science, and Cochrane Library databases up to December 25, 2022. The association between PD-L1, TILs, and survival outcomes was evaluated using the combined hazard ratios (HRs) and their corresponding 95% confidence intervals (CIs).
UNASSIGNED: This meta-analysis comprised 11 trials involving a total of 1746 cases. The results revealed no significant association between PD-L1 expression in tumor cells (TCs) and overall survival (OS, HR = 0.76, 95% CI: 0.52-1.09, p = 0.136) or progression-free survival (PFS, HR = 0.71, 95% CI: 0.4 -1.24, p = 0.230). Nevertheless, a correlation was observed between PD-L1 expression in immune cells (ICs) and OS (HR = 0.73, 95% CI: 0.55-0.97, p = 0.031). Furthermore, the presence of CD8+ and PD-1+ TILs was found to significantly enhance OS (HR = 0.70, 95% CI = 0.55-0.87, p = 0.002; HR = 0.57, 95% CI = 0.40-0.80, p = 0.001, respectively) and PFS (HR = 0.62, 95% CI = 0.41-0.92, p = 0.019; HR = 0.52, 95% CI = 0.35-0.78, p = 0.002, respectively), whereas the presence of CD3+ and CD4+ TILs was positively associated with OS (HR = 0.50, 95% CI = 0.29-0.87, p = 0.014; HR = 0.55, 95% CI = 0.34-0.91, p = 0.020, respectively).
UNASSIGNED: This study indicates a positive correlation between ICs-derived PD-L1 and survival, while no significant correlation was observed between TCs-derived PD-L1 and prognosis. These results highlight the importance of studying PD-L1 expression in ICs as a prognostic predictor. In addition, the presence of TILs was found to significantly improve patient survival, suggesting that TILs may be a valuable prognostic biomarker.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/, identifier CRD42022366411.