在这篇文章中,我们回顾了数学建模在阐明肿瘤相关巨噬细胞(TAMs)在肿瘤进展和治疗设计中的作用.我们首先概述TAM的生物学,以及它目前在肿瘤治疗中的应用,和他们的实验方法提供了对肿瘤细胞-巨噬细胞相互作用的见解。然后,我们专注于描述巨噬细胞作为药物载体的作用的机械数学模型,巨噬细胞极化激活对肿瘤生长的影响,以及肿瘤微环境(TME)参数对肿瘤-巨噬细胞相互作用的作用。这篇综述旨在确定生物学和数学方法之间的协同作用,使我们能够翻译有关基本TAM生物学的知识,以应对当前的临床挑战。
In this article, we
review the role of mathematical modelling to elucidate the impact of tumor-associated macrophages (TAMs) in tumor progression and therapy design. We first outline the biology of TAMs, and its current application in tumor therapies, and their experimental methods that provide insights into tumor cell-macrophage interactions. We then focus on the mechanistic mathematical models describing the role of macrophages as drug carriers, the impact of macrophage polarized activation on tumor growth, and the role of tumor microenvironment (TME) parameters on the tumor-macrophage interactions. This
review aims to identify the synergies between biological and mathematical approaches that allow us to translate knowledge on fundamental TAMs biology in addressing current clinical challenges.