背景:我们的目的是研究血浆TrxR活性作为胃肠道恶性肿瘤早期诊断的有效工具的合理性和准确性,以及TrxR是否可用于评价胃肠道恶性肿瘤的治疗效果。
方法:我们共纳入5091例,包括3736例胃肠道恶性肿瘤,964良性疾病,和391例健康对照。我们还进行了接收器工作特性(ROC)分析,以评估TrxR的诊断效率。最后,我们检测了治疗前后的TrxR水平和常见肿瘤标志物。
结果:胃肠道恶性肿瘤患者血浆TrxR水平[8.4(6.9,9.7)U/mL]高于良性疾病患者[5.8(4.6,6.9)U/mL]和健康对照组[3.5(1.4,5.4)U/mL]。与常规肿瘤标志物相比,血浆TrxR显示出显著的诊断优势,AUC为0.897。此外,将TrxR与常规肿瘤标志物联合使用可进一步提高诊断效率。根据Youden指数6.15U/mL,我们得出了血浆TrxR作为胃肠道恶性肿瘤诊断标志物的最佳临界值。测定抗肿瘤治疗前后TrxR活性和常规肿瘤标志物的变化趋势,我们发现它们的变化趋势基本一致,化疗患者血浆TrxR活性明显下降,靶向治疗和免疫治疗。
结论:我们的研究结果表明,血浆TrxR活性可作为胃肠道恶性肿瘤早期诊断的有效工具和评估治疗效果的可行工具。
BACKGROUND: Our aim was to investigate the rationality and accuracy of plasma
TrxR activity as an efficient tool in the early diagnosis of gastrointestinal malignancy, and whether
TrxR can be used to evaluate the therapeutic efficacy of gastrointestinal malignancy.
METHODS: We enrolled a total of 5091 cases, including 3736 cases in gastrointestinal malignancy, 964 in benign diseases, and 391 cases in healthy controls. We also performed receiver operating characteristic (ROC) analysis to evaluate diagnostic efficiency of TrxR. Finally, we detected pre- and post-treatment level of
TrxR and common tumor markers.
RESULTS: The plasma
TrxR level in patients with gastrointestinal malignancy [8.4 (6.9, 9.7) U/mL] was higher than that in patients with benign disease [5.8 (4.6, 6.9) U/mL] and healthy control [3.5 (1.4, 5.4) U/mL]. Plasma
TrxR showed a significant diagnostic advantage with an AUC of 0.897, compared with conventional tumor markers. In addition, the combination of TrxR and conventional tumor markers can further improve the diagnostic efficiency. We derived the optimal cut-off value of plasma TrxR as a diagnostic marker of gastrointestinal malignancy according to Youden index of 6.15 U/mL. After measuring the change trend of TrxR activity and conventional tumor markers before and after anti-tumor treatments, we found that their change trend was generally consistent, and the plasma TrxR activity was significantly decreased in patients treated with chemotherapy, targeted therapy and immunotherapy.
CONCLUSIONS: Our findings recommend that plasma TrxR activity could be monitored as an efficient tool for the early diagnosis of gastrointestinal malignancy and as a feasible tool to evaluate the therapeutic effect.