由于BFR最近逐渐被禁止,有机磷阻燃剂(OPFRs)已经被制造和使用。尽管OPFRs被认为是BFR的更好替代品,许多研究发现OPFRs可能与各种癌症有关,包括前列腺癌,膀胱癌,肝细胞癌,还有结直肠癌.然而,很少有研究探讨OPFRs与胶质瘤之间的关系。本研究使用生物信息学分析方法研究了磷酸三苯酯(TPP)与神经胶质瘤之间的关系。比较毒性基因组学数据库(CTD)和癌症基因组图谱(TCGA)数据库被访问以获得来自神经胶质瘤患者的TPP相关基因和基因表达数据。基因本体论(GO)富集和京都基因和基因组百科全书(KEGG)富集分析表明,TPP可能与许多途径密切相关。Further,蛋白质-蛋白质相互作用的分析揭示了TPP相关基因之间很强的内在关系。此外,基于TPP的预后预测模型在预测胶质瘤患者的预后方面显示了有希望的结果.一些TPP相关基因与胶质瘤患者的总体生存率密切相关。TPP进一步证明了胶质瘤细胞的增殖和迁移能力。在生物信息学分析中,我们还发现褪黑激素与TPP和胶质瘤的存在高度相关。根据细胞增殖和迁移试验,与TPP组相比,暴露于褪黑素和TPP抑制了神经胶质瘤细胞的侵袭能力。
As BFRs have gradually been banned recently, organophosphorus flame retardants (OPFRs) have been manufactured and used in their place. Although OPFRs are considered the better alternatives to BFRs, many studies have discovered that OPFRs may be associated with various cancers, including prostate cancer, bladder cancer, hepatocellular carcinoma, and colorectal cancer. However, few studies have examined the relationship between OPFRs and gliomas. This
study investigated the relationship between triphenyl phosphate (TPP) and glioma using bioinformatics analysis approaches. The comparative toxicogenomics database (CTD) and The Cancer Genome Atlas (TCGA) databases were accessed for TPP-related genes and gene expression data from glioma patients. The Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses show that TPP might be closely related to many pathways. Further, the analysis of protein-protein interactions revealed strong intrinsic relationships between TPP-related genes. In addition, the TPP-based prognostic prediction model demonstrated promising results in predicting the prognosis of patients with gliomas. Several TPP-related genes were closely related to glioma patients\' overall survival rates. The proliferation and migration abilities of glioma cells were further demonstrated to be significantly enhanced by TPP. In a bioinformatics analysis, we also discovered that melatonin is highly correlated with the presence of TPP and gliomas. According to the cell proliferation and migration assays, exposure to melatonin and TPP inhibited the ability of glioma cells to invade compared with the TPP group.