■桥本甲状腺炎(HT),影响甲状腺功能的慢性自身免疫性疾病,是一个日益增长的公共卫生问题。Treg细胞与HT的关系已被广泛研究,Treg细胞被认为对抑制HT进展至关重要。然而,这些研究主要是观察性的,限制了我们对Treg细胞对HT风险的影响的理解。利用大型数据集,我们利用孟德尔随机化(MR)分析来检查Treg细胞生物标志物与HT之间的因果关系,为这些关系提供额外的验证。
■在这项研究中,进行了全面的双样本孟德尔随机化分析,以确定Treg细胞特征与HT之间的因果关系。根据公开的基因数据,我们探讨了165个Treg细胞特征与HT风险之间的因果关系.
■欧洲队列研究已经确定了五种Treg细胞表型,这些表型在因果关系上可以预防HT风险。静息Treg%CD4(OR=0.975,95%CI=0.954〜0.998,P=0.030);静息Treg上的CD4(OR=0.938,95%CI=0.882〜0.997,P=0.041;CD28-CD8dim%CD8dim(OR=0.983,95%CI=0.969〜0.998,P=0.030);CD25上的CD25+静息Tre亚洲队列研究确定了四种与HT风险负相关的Treg细胞表型。CD25h%T细胞(OR=0.635,95%CI=0.473~852,P=0.002);CD4Treg%CD4(OR=0.829,95%CI=0.687~1.000,P=0.050);CD127-CD8br%T细胞(OR=0.463,95%CI=0.311~0.687,P<0.001);CD3对Treg的影响(OR=0.721,0.
■我们的研究通过遗传手段证明了Treg细胞与HT之间的紧密联系,从而为今后的研究提供了基础依据。
UNASSIGNED: Hashimoto\'s thyroiditis (HT), a chronic autoimmune disorder impacting thyroid function, is a growing public health concern. The relationship between Treg cells and HT has been extensively studied, with Treg cells considered crucial in suppressing HT progression. However, these studies have mainly been observational, limiting our understanding of Treg cells\' impact on HT risk. Leveraging large datasets, we utilized Mendelian randomization (MR) analysis to examine the causal association between Treg cell biomarkers and HT, providing additional validation for these relationships.
UNASSIGNED: Comprehensive two-sample Mendelian randomization analysis was performed to determine the causal association between Treg cells signatures and HT in this
study. Based on publicly available genetic data, we explored causal associations between 165 Treg cells signatures and HT risk.
UNASSIGNED: The European cohort
study has identified five Treg cell phenotypes that causally protect against HT risk. Resting Treg %CD4 (OR = 0.975, 95% CI = 0.954~0.998, P = 0.030); CD4 on resting Treg (OR = 0.938, 95% CI = 0.882~0.997, P = 0.041; CD28- CD8dim %CD8dim (OR = 0.983, 95% CI = 0.969~0.998, P = 0.030); CD25 on CD39+ resting Treg (OR = 0.926, 95% CI = 0.864~0.991, P = 0.026); 5) CD28 on activated & secreting Treg (OR = 0.969, 95% CI = 0.942~0.996, P = 0.025). The Asian cohort
study has identified four Treg cell phenotypes negatively correlated with the risk of HT. CD25hi %T cell (OR = 0.635, 95% CI = 0.473~852, P = 0.002); CD4 Treg %CD4 (OR = 0.829, 95% CI = 0.687~1.000, P = 0.050); CD127-CD8br %T cell (OR = 0.463, 95% CI =0.311~0.687, P< 0.001); CD3 on resting Treg (OR = 0.786, 95% CI = 0.621~0.994, P = 0.044).
UNASSIGNED: Our
study has demonstrated the close connection between Treg cells and HT by genetic means, thus providing foundational basis for future research.