口咽鳞状细胞癌是头颈癌的一种独特亚型,在过去的四十年中,它与人乳头瘤病毒的联系越来越紧密。描述了两个兄弟相隔6年被诊断为人乳头瘤病毒阳性口咽鳞状细胞癌的病例。第一个哥哥,R.M.,有8个月的扁桃体肿胀史,发现III期人乳头瘤病毒阳性口咽鳞状细胞癌。尽管化疗延迟治疗,他患上了转移性疾病,并死于疾病。二哥,K.M.,鉴于他的家族史,在颈部肿胀发展后仅三周,也被诊断为III期人乳头瘤病毒阳性口咽鳞状细胞癌。迅速放化疗和颈淋巴结清扫后,K.M.已经缓解了9年。文献尚未描述人类乳头瘤病毒阳性口咽鳞状细胞癌的这种家族聚集程度。因此,这引入了人乳头瘤病毒在口咽部发生的遗传易感性的可能性。该病例强调了临床医生对人类乳头瘤病毒家族史保持警惕的重要性。以及对研究遗传畸变与人乳头瘤病毒致癌过程的相互作用的未来研究具有重要意义。
Oropharyngeal squamous cell carcinoma is a distinct subtype of head and neck cancer that has become increasingly linked to human papillomavirus over the last four decades. Described is the
case of two brothers diagnosed with human papillomavirus-positive oropharyngeal squamous cell carcinoma 6 years apart. The first brother, R.M., presented with an 8-month history of tonsillar swelling, found to be stage III human papillomavirus-positive oropharyngeal squamous cell carcinoma. Despite delayed treatment with chemoradiation, he developed metastatic disease and succumbed to his illness. The second brother, K.M., presented only 3 weeks after the development of neck swelling given his family history, which was also diagnosed as stage III human papillomavirus-positive oropharyngeal squamous cell carcinoma. Following prompt chemoradiation and neck dissection, K.M. has remained in remission for 9 years. Literature has yet to characterize this degree of familial clustering among human papillomavirus-positive oropharyngeal squamous cell carcinomas. Hence, this introduces the possibility of a genetic predisposition to human papillomavirus\'s oncogenesis in the oropharynx. This
case emphasizes the importance for clinicians to stay vigilant of the family history of human papillomavirus, as well as poses significant implications for future research investigating the interaction of genetic aberrations on human papillomavirus\'s oncogenic process.