目的:评估短期暴露于<2.5μm的整体细颗粒物(PM2.5)和特定于野火的PM2.5与急诊(ED)就诊头痛的关系。
背景:研究报告了PM2.5暴露与头痛风险之间的关联。随着气候变化导致更长时间和更强烈的野火季节,野火PM2.5可能导致更频繁的头痛。
方法:我们的研究纳入了2006年至2020年大型去识别的商业和MedicareAdvantage索赔数据库的成年加利福尼亚成员(年龄≥18岁)。我们确定了原发性头痛疾病的ED就诊(亚型:紧张型头痛,偏头痛,丛集性头痛,和“其他”原发性头痛)。索赔包括成员年龄,性别,和住宅邮政编码。我们将每日整体和特定于野火的PM2.5与住宅邮政编码联系起来,并考虑了7天的平均PM2.5浓度,进行了时间分层的病例交叉分析。首先是原发性头痛疾病的合并,然后是头痛亚型。
结果:在9898名独特个体中,我们确定了13,623名原发性头痛疾病的ED发作。偏头痛是最常见的头痛(N=5534/13,623[47.6%]),其次是“其他”原发性头痛(N=6489/13,623[40.6%])。对于所有原发性头痛ED诊断,我们观察到7天平均野火PM2.5的关联(比值比[OR]1.17,95%置信区间[CI]0.95-1.44每10μg/m3增加),并且根据亚型,我们观察到ED就诊的几率增加与紧张型头痛的7天平均野火PM2.5相关(OR1.42,95%CI0.91-2.22),“其他”原发性头痛(OR1.40,95%CI0.96-2.05),和丛集性头痛(OR1.29,95%CI0.71-2.35),尽管在传统的零假设测试下,这些发现没有统计学意义。整体PM2.5与紧张型头痛相关(OR1.29,95%CI1.03-1.62),但不是偏头痛,群集,或“其他”原发性头痛。
结论:虽然不精确,这些结果表明,短期野火PM2.5暴露可能与头痛的ED就诊有关.患者,医疗保健提供者,在野火过后和空气质量差的日子里,系统可能需要应对与头痛相关的医疗保健需求增加。
To evaluate the association of short-term exposure to overall fine particulate matter of <2.5 μm (PM2.5 ) and wildfire-specific PM2.5 with emergency department (ED) visits for headache.
Studies have reported associations between PM2.5 exposure and headache risk. As climate change drives longer and more intense wildfire seasons, wildfire PM2.5 may contribute to more frequent headaches.
Our study included adult Californian members (aged ≥18 years) of a large de-identified commercial and Medicare Advantage claims database from 2006 to 2020. We identified ED visits for primary headache disorders (subtypes: tension-type headache, migraine headache, cluster headache, and \"other\" primary headache). Claims included member age, sex, and residential zip code. We linked daily overall and wildfire-specific PM2.5 to residential zip code and conducted a time-stratified
case-crossover analysis considering 7-day average PM2.5 concentrations, first for primary headache disorders combined, and then by headache subtype.
Among 9898 unique individuals we identified 13,623 ED encounters for primary headache disorders. Migraine was the most frequently diagnosed headache (N = 5534/13,623 [47.6%]) followed by \"other\" primary headache (N = 6489/13,623 [40.6%]). For all primary headache ED diagnoses, we observed an association of 7-day average wildfire PM2.5 (odds ratio [OR] 1.17, 95% confidence interval [CI] 0.95-1.44 per 10 μg/m3 increase) and by subtype we observed increased odds of ED visits associated with 7-day average wildfire PM2.5 for tension-type headache (OR 1.42, 95% CI 0.91-2.22), \"other\" primary headache (OR 1.40, 95% CI 0.96-2.05), and cluster headache (OR 1.29, 95% CI 0.71-2.35), although these findings were not statistically significant under traditional null hypothesis testing. Overall PM2.5 was associated with tension-type headache (OR 1.29, 95% CI 1.03-1.62), but not migraine, cluster, or \"other\" primary headaches.
Although imprecise, these results suggest short-term wildfire PM2.5 exposure may be associated with ED visits for headache. Patients, healthcare providers, and systems may need to respond to increased headache-related healthcare needs in the wake of wildfires and on poor air quality days.