这个全国范围内,以人口为基础,回顾性,匹配的病例对照研究包括4334例新诊断的Fuchs内皮营养不良（FED）患者，他们被国际疾病分类鉴定，第九次修订,临床修改（ICD-9-CM），代码371.57，并从台湾国民健康保险研究数据库中选择。年龄-，sex-,与指数日期匹配的对照组包括从2000年台湾纵向健康保险数据库中选择的4334名非FED对照。使用单变量逻辑回归分析检查眼部过敏状况和社会人口统计学状况，并对连续变量使用配对t检验。使用调整后的逻辑回归比较FED发展的比值比（OR）。即使进行了条件逻辑回归（调整后的OR=25.26，95％CI=11.24-56.77，p<0.0001），眼部过敏性疾病的患者也比对照组更容易发生FED（OR=25.50，95％CI=12.58-51.68，p<0.0001）。关于社会人口因素，我们发现，台湾超过一半的FED患者年龄≥45岁，男女比例相等(1.06:1)，收入较低且居住在台湾北部的患者患FED的几率较高。结果强烈支持眼部过敏状况之间的关联，地理区域,居住状态,收入,和FED。
This nationwide, population-based, retrospective, matched
case-control study included 4334 newly diagnosed Fuchs\' endothelial dystrophy (FED) patients who were identified by the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM), code 371.57, and selected from the Taiwan National Health Insurance Research Database. The age-, sex-, and index-date-matched control group included 4334 non-FED controls selected from the Taiwan Longitudinal Health Insurance Database 2000. Ocular allergic conditions and sociodemographic conditions were examined using univariate logistic regression analyses and paired t-test was used for continuous variables. Adjusted logistic regression was used to compare the odds ratio (OR) of the FED development. Patients with ocular allergic conditions were more likely to have FED than the controls (OR = 25.50, 95% CI = 12.58-51.68, p < 0.0001) even after conditional logistic regression was conducted (adjusted OR = 25.26, 95% CI = 11.24-56.77, p < 0.0001). Regarding the sociodemographic factors, we found that more than half of the FED patients in Taiwan were aged ≥45 years old, there was an equal female-to-male ratio (1.06:1), and patients with a lower income and living in northern Taiwan had higher odds of developing FED. The results strongly support an association between ocular allergic conditions, geographic region, residential status, income, and FED.
