带菌者和囊虫病,是由牛带虫引起的,猪带虫和亚洲带虫,是人畜共患寄生虫感染,在世界范围内具有重大的疾病负担。专家们一致认为,与囊虫病相反,沙吉纳塔是一种常见的tape虫,会引起人类的带虫病。这个在2021年进行的中年藏族男子的案例研究挑战了流行的观念,即T.saginata通过记录与taeniasis和多发性囊虫病有关的症状和实验室研究,仅引起taeniasis而不是囊虫病。对患者的病历进行了回顾,该患者的症状为带菌病和囊虫病,并且通过形态学评估从患者中鉴定出tape虫的proglottis和囊肿,DNA扩增和测序。患者经常经历严重的头痛和呕吐。常规血液筛查和针对最常见寄生虫的抗体测试均正常。驱虫治疗后,在粪便中发现了一条成虫,医学影像学检查提示患者的大脑和肌肉中有多个局灶性结节。前声门的形态学和分子诊断显示,Cestoda是T.saginata。尽管囊肿的形态带来了挑战,分子分析表明,它最有可能是T.saginata。该案例研究表明,人类中的T.saginata感染有可能导致人类囊虫病。然而,这样的结论需要通过准确的全基因组分析来审查与囊肿相关的沙氏杆菌病患者。这样的研究将提供对T.saginata致病性的新见解。
Taeniasis and cysticercosis, which are caused by Taenia saginata, Taenia solium and Taenia asiatica, are zoonotic parasitic infections with a significant disease burden worldwide. There is consensus amongst experts that T. saginata is a common tapeworm that causes taeniasis in humans as opposed to cysticercosis. This
case study of a middle-aged Tibetan man conducted in 2021 challenges the prevailing notion that T. saginata exclusively causes taeniasis and not cysticercosis by documenting symptoms and laboratory studies related to both taeniasis and multiple cysticercosis. The patient\'s medical record with the symptoms of taeniasis and cysticercosis was reviewed, and the tapeworm\'s proglottids and cyst were identified from the patient by morphological evaluation, DNA amplification and sequencing. The patient frequently experienced severe headaches and vomiting. Both routine blood screenings and testing for antibodies against the most common parasites were normal. After anthelmintic treatment, an adult tapeworm was found in feces, and medical imaging examinations suggested multiple focal nodules in the brain and muscles of the patient. The morphological and molecular diagnosis of the proglottids revealed the Cestoda was T. saginata. Despite the challenges presented by the cyst\'s morphology, the molecular analysis suggested that it was most likely T. saginata. This
case study suggests that T. saginata infection in humans has the potential to cause human cysticercosis. However, such a conclusion needs to be vetted by accurate genome-wide analysis in patients with T. saginata taeniasis associated with cysts. Such studies shall provide new insights into the pathogenicity of T. saginata.