背景:八聚体4(10月4日),POU结构域转录因子家族的重要成员,已被建议在人类体细胞分化过程中充当主开关,并且最近已与肿瘤特性有关。这项研究的目的是使用荟萃分析方法评估Oct-4与癌症分期之间的关系。
方法:截至2015年5月发表的相关文章从以下数据库中检索:PubMed,ISIWebofKnowledge,Embase,和中国国家知识基础设施(CNKI)。根据比值比(OR)和95%置信区间(CI)估计感兴趣结果的关系强度。
结果:选择了10月4日和癌症分期共11篇文章,共包括502例阳性/高Oct-4例和522例阴性/低无病例对照。在几种癌症中,Oct-4阳性/高与癌症分期显着相关。具体来说,阳性/高Oct-4与癌症III/IV期相关(固定效应:OR=1.53,95%CI=1.12-2.10),原发肿瘤(T3-4)(随机效应:OR=1.93,95%CI=0.99-3.77),和癌症分化程度(中差)(随机效应:OR=3.45,95%CI=1.5-7.61)。
结论:这些研究结果表明,阳性/高Oct-4与III/IV期癌症和癌症分化等级更密切相关,并且与导致不同类型癌症预后不良的恶性特征相关,尤其是在亚洲。鉴于与种族相关的变异性和癌症类型的差异,我们需要更多的研究来确定我们研究结果的普遍性.
BACKGROUND: Octamer 4 (Oct-4), an important member of the POU domain transcription factor family, has been suggested to function as a master switch during differentiation of human somatic cells and more recently has come to be linked with neoplastic properties. The aim of this study was to evaluate the relationship between Oct-4 and cancer stage using a meta-analysis approach.
METHODS: Relevant articles published as of May 2015 were retrieved from the following databases: PubMed, ISI Web of Knowledge, Embase, and Chinese National Knowledge Infrastructure (CNKI). The strengths of relationship for outcomes of interest were estimated based on odds ratios (ORs) and 95% confidence intervals (CIs).
RESULTS: A total of 11 articles on Oct-4 and cancer staging that collectively included 502 positive/high Oct-4 cases and 522 negative/low
case-free controls were chosen. Positive/high Oct-4 was significantly associated with cancer stage in several kinds of cancer. Specifically, positive/high Oct-4 was associated with cancer stage III/IV (fixed effects: OR = 1.53, 95% CI = 1.12-2.10), primary tumor (T3-4) (random effects: OR = 1.93, 95% CI = 0.99-3.77), and cancer grade of differentiation (intermediate-poor) (random effects: OR = 3.45, 95% CI = 1.5-7.61).
CONCLUSIONS: These findings suggest that positive/high Oct-4 is more strongly linked to stage III/IV cancer and cancer grade of differentiation, and is correlated with malignant characteristics that lead to poor prognosis in different types of cancer, especially in Asian. Given variability related to ethnicity and differences in cancer types, additional studies are warranted to establish the generalizability of our findings.