NF-κB通路在阻碍糖尿病创面愈合过程中起着关键作用,导致长时间的炎症,血管生成减少,减少扩散。与现代合成疗法相反,天然存在的植物成分是经过充分研究的NF-κB途径的抑制剂,由于毒性较低,现在在糖尿病伤口愈合方面引起了越来越多的关注,更好的安全性和有效性,和成本效益。这项研究探索了基于植物成分的疗法的最新研究,并深入研究了它们针对NF-κB途径的作用机制以及协助糖尿病伤口有效愈合的潜力。为此,我们对最近的文献进行了调查,并分析了来自著名数据库的研究,如ScienceDirect,Scopus,PubMed,谷歌学者,EMBASE,和WebofScience。将植物成分分为不同类别,例如:生物碱,三萜类,酚类物质,多酚,黄酮类化合物,单萜苷,萘醌和生育酚。值得注意的植物成分,包括Neferine,Plumbagin,乳香酸,金雀异黄素,木犀草素,Kirenol,芦丁,维克宁-2,γ-生育酚,淫羊藿苷,白藜芦醇,芒果苷,桦木酸,小檗碱,丁香酸,Gallocatechin,姜黄素,Loureirin-A,Loureirin-B,Lupeol,芍药苷,和葛根素从这些研究中通过抑制NF-κB途径成为糖尿病伤口愈合的有前途的药物。对各种植物成分的广泛研究揭示了它们如何调节信号通路,包括NF-κB,研究证明了开发治疗性植物成分以帮助慢性糖尿病伤口愈合的潜力。
The NF-κB pathway plays a pivotal role in impeding the diabetic wound healing process, contributing to prolonged inflammation, diminished angiogenesis, and reduced proliferation. In contrast to modern synthetic therapies, naturally occurring phytoconstituents are well-studied inhibitors of the NF-κB pathway that are now attracting increased attention in the context of diabetic wound healing because of lower toxicity, better safety and efficacy, and cost-effectiveness. This study explores recent research on phytoconstituent-based therapies and delve into their action mechanisms targeting the NF-κB pathway and potential for assisting effective healing of diabetic wounds. For this purpose, we have carried out surveys of recent literature and analyzed studies from prominent databases such as Science Direct, Scopus, PubMed, Google Scholar, EMBASE, and Web of Science. The classification of phytoconstituents into various categorie such as: alkaloids, triterpenoids, phenolics, polyphenols, flavonoids, monoterpene glycosides, naphthoquinones and tocopherols. Noteworthy phytoconstituents, including Neferine, Plumbagin, Boswellic acid, Genistein, Luteolin, Kirenol, Rutin, Vicenin-2, Gamma-tocopherol, Icariin, Resveratrol, Mangiferin, Betulinic acid, Berberine, Syringic acid, Gallocatechin, Curcumin, Loureirin-A, Loureirin-B, Lupeol, Paeoniflorin, and Puerarin emerge from these studies as promising agents for diabetic wound healing through the inhibition of the NF-κB pathway. Extensive research on various phytoconstituents has revealed how they modulate signalling pathways, including NF-κB, studies that demonstrate the potential for development of therapeutic phytoconstituents to assist healing of chronic diabetic wounds.